P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities

BACKGROUND: Human Tau (hTau) accumulation and synapse loss are two pathological hallmarks of tauopathies. However, whether and how hTau exerts toxic effects on synapses remain elusive. METHODS: Mutated hTau (P301S) was overexpressed in the N2a cell line, primary hippocampal neurons and hippocampal C...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Jia‐Zhao, Zhang, Yao, Li, Shi‐Hong, Wei, Hui, Yu, Hui‐Ling, Zhou, Qiu‐Zhi, Wei, Lin‐Yu, Ke, Dan, Wang, Qun, Yang, Ying, Wang, Jian‐Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345400/
https://www.ncbi.nlm.nih.gov/pubmed/35917404
http://dx.doi.org/10.1002/ctm2.1003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345400/
https://www.ncbi.nlm.nih.gov/pubmed/35917404
http://dx.doi.org/10.1002/ctm2.1003

Ejemplares similares