Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice

The present study intends to use microspheres as a delivery system of chlorogenic acid (CGA) to investigate the influences of CGA microspheres on dietary fat absorption and fecal triglyceride excretion in a mice model. Microspheres have an average particle size of about 53.3 μm. Results indicated that the microspheres were capable of gradually releasing the preloaded CGA into the surrounding medium. Their bioadhesive property might help prolong the gastrointestinal transit time in mice, and render a better mixing and contact between CGA and triglyceride. Consumption of CGA microspheres resulted in a significantly higher level of fecal triglyceride (119–144%) as compared with the corresponding control groups. A microsphere would be a desirable vehicle for CGA to improve its efficacy along the intestine.