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Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions

The effect of different high pressure homogenization energy input parameters on mean diameter droplet size (MDS) and droplets with > 5 μm of lipid injectable emulsions were evaluated. All emulsions were prepared at different water bath temperatures or at different rotation speeds and rotor-stator...

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Detalles Bibliográficos
Autores principales: Peng, Jie, Dong, Wu-jun, Li, Ling, Xu, Jia-ming, Jin, Du-jia, Xia, Xue-jun, Liu, Yu-ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345441/
https://www.ncbi.nlm.nih.gov/pubmed/28911501
http://dx.doi.org/10.1016/j.jfda.2015.04.004
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author Peng, Jie
Dong, Wu-jun
Li, Ling
Xu, Jia-ming
Jin, Du-jia
Xia, Xue-jun
Liu, Yu-ling
author_facet Peng, Jie
Dong, Wu-jun
Li, Ling
Xu, Jia-ming
Jin, Du-jia
Xia, Xue-jun
Liu, Yu-ling
author_sort Peng, Jie
collection PubMed
description The effect of different high pressure homogenization energy input parameters on mean diameter droplet size (MDS) and droplets with > 5 μm of lipid injectable emulsions were evaluated. All emulsions were prepared at different water bath temperatures or at different rotation speeds and rotor-stator system times, and using different homogenization pressures and numbers of high-pressure system recirculations. The MDS and polydispersity index (PI) value of the emulsions were determined using the dynamic light scattering (DLS) method, and large-diameter tail assessments were performed using the light-obscuration/single particle optical sensing (LO/SPOS) method. Using 1000 bar homogenization pressure and seven recirculations, the energy input parameters related to the rotor-stator system will not have an effect on the final particle size results. When rotor-stator system energy input parameters are fixed, homogenization pressure and recirculation will affect mean particle size and large diameter droplet. Particle size will decrease with increasing homogenization pressure from 400 bar to 1300 bar when homogenization recirculation is fixed; when the homogenization pressure is fixed at 1000 bar, the particle size of both MDS and percent of fat droplets exceeding 5 μm (PFAT(5)) will decrease with increasing homogenization recirculations, MDS dropped to 173 nm after five cycles and maintained this level, volume-weighted PFAT(5) will drop to 0.038% after three cycles, so the “plateau” of MDS will come up later than that of PFAT(5), and the optimal particle size is produced when both of them remained at plateau. Excess homogenization recirculation such as nine times under the 1000 bar may lead to PFAT(5) increase to 0.060% rather than a decrease; therefore, the high-pressure homogenization procedure is the key factor affecting the particle size distribution of emulsions. Varying storage conditions (4–25°C) also influenced particle size, especially the PFAT(5).
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spelling pubmed-93454412022-08-09 Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions Peng, Jie Dong, Wu-jun Li, Ling Xu, Jia-ming Jin, Du-jia Xia, Xue-jun Liu, Yu-ling J Food Drug Anal Original Article The effect of different high pressure homogenization energy input parameters on mean diameter droplet size (MDS) and droplets with > 5 μm of lipid injectable emulsions were evaluated. All emulsions were prepared at different water bath temperatures or at different rotation speeds and rotor-stator system times, and using different homogenization pressures and numbers of high-pressure system recirculations. The MDS and polydispersity index (PI) value of the emulsions were determined using the dynamic light scattering (DLS) method, and large-diameter tail assessments were performed using the light-obscuration/single particle optical sensing (LO/SPOS) method. Using 1000 bar homogenization pressure and seven recirculations, the energy input parameters related to the rotor-stator system will not have an effect on the final particle size results. When rotor-stator system energy input parameters are fixed, homogenization pressure and recirculation will affect mean particle size and large diameter droplet. Particle size will decrease with increasing homogenization pressure from 400 bar to 1300 bar when homogenization recirculation is fixed; when the homogenization pressure is fixed at 1000 bar, the particle size of both MDS and percent of fat droplets exceeding 5 μm (PFAT(5)) will decrease with increasing homogenization recirculations, MDS dropped to 173 nm after five cycles and maintained this level, volume-weighted PFAT(5) will drop to 0.038% after three cycles, so the “plateau” of MDS will come up later than that of PFAT(5), and the optimal particle size is produced when both of them remained at plateau. Excess homogenization recirculation such as nine times under the 1000 bar may lead to PFAT(5) increase to 0.060% rather than a decrease; therefore, the high-pressure homogenization procedure is the key factor affecting the particle size distribution of emulsions. Varying storage conditions (4–25°C) also influenced particle size, especially the PFAT(5). Taiwan Food and Drug Administration 2015-05-19 /pmc/articles/PMC9345441/ /pubmed/28911501 http://dx.doi.org/10.1016/j.jfda.2015.04.004 Text en © 2015 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Peng, Jie
Dong, Wu-jun
Li, Ling
Xu, Jia-ming
Jin, Du-jia
Xia, Xue-jun
Liu, Yu-ling
Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions
title Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions
title_full Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions
title_fullStr Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions
title_full_unstemmed Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions
title_short Effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions
title_sort effect of high-pressure homogenization preparation on mean globule size and large-diameter tail of oil-in-water injectable emulsions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345441/
https://www.ncbi.nlm.nih.gov/pubmed/28911501
http://dx.doi.org/10.1016/j.jfda.2015.04.004
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