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Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA

Esophageal cancer (ESCA) is a malignant tumor of the upper gastrointestinal tract, with a high mortality rate and poor prognosis. Long noncoding RNAs (lncRNAs) play a role in the malignant progression of tumors by regulating autophagy. This study is aimed at establishing a prognostic model of autoph...

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Detalles Bibliográficos
Autores principales: Chen, Feifei, Zhang, Jian, Bai, Wenxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345713/
https://www.ncbi.nlm.nih.gov/pubmed/35928921
http://dx.doi.org/10.1155/2022/9265088
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author Chen, Feifei
Zhang, Jian
Bai, Wenxia
author_facet Chen, Feifei
Zhang, Jian
Bai, Wenxia
author_sort Chen, Feifei
collection PubMed
description Esophageal cancer (ESCA) is a malignant tumor of the upper gastrointestinal tract, with a high mortality rate and poor prognosis. Long noncoding RNAs (lncRNAs) play a role in the malignant progression of tumors by regulating autophagy. This study is aimed at establishing a prognostic model of autophagy-related lncRNAs in ESCA and provide a theoretical basis to determine potential therapeutic targets for ESCA. The transcriptome expression profiles were downloaded from The Cancer Genome Atlas (TCGA). We identified autophagy-related mRNAs and lncRNAs in ESCA using differential expression analysis and the Human Autophagy Database (HADb). Four differentially expressed autophagy-related lncRNAs with a prognostic value were identified using Cox regression and survival analyses. Furthermore, the combination of the selected lncRNAs was able to predict the prognosis of patients with ESCA more accurately than any of the four lncRNAs individually. Finally, we constructed a coexpression network of autophagy-related mRNAs and lncRNAs. This study showed that autophagy-related lncRNAs play an important role in the occurrence and development of ESCA and could become a new target for the diagnosis and treatment of this disease.
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spelling pubmed-93457132022-08-03 Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA Chen, Feifei Zhang, Jian Bai, Wenxia Biomed Res Int Research Article Esophageal cancer (ESCA) is a malignant tumor of the upper gastrointestinal tract, with a high mortality rate and poor prognosis. Long noncoding RNAs (lncRNAs) play a role in the malignant progression of tumors by regulating autophagy. This study is aimed at establishing a prognostic model of autophagy-related lncRNAs in ESCA and provide a theoretical basis to determine potential therapeutic targets for ESCA. The transcriptome expression profiles were downloaded from The Cancer Genome Atlas (TCGA). We identified autophagy-related mRNAs and lncRNAs in ESCA using differential expression analysis and the Human Autophagy Database (HADb). Four differentially expressed autophagy-related lncRNAs with a prognostic value were identified using Cox regression and survival analyses. Furthermore, the combination of the selected lncRNAs was able to predict the prognosis of patients with ESCA more accurately than any of the four lncRNAs individually. Finally, we constructed a coexpression network of autophagy-related mRNAs and lncRNAs. This study showed that autophagy-related lncRNAs play an important role in the occurrence and development of ESCA and could become a new target for the diagnosis and treatment of this disease. Hindawi 2022-07-26 /pmc/articles/PMC9345713/ /pubmed/35928921 http://dx.doi.org/10.1155/2022/9265088 Text en Copyright © 2022 Feifei Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Feifei
Zhang, Jian
Bai, Wenxia
Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA
title Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA
title_full Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA
title_fullStr Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA
title_full_unstemmed Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA
title_short Establishment and Analysis of a Prognostic Model of Autophagy-Related lncRNAs in ESCA
title_sort establishment and analysis of a prognostic model of autophagy-related lncrnas in esca
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345713/
https://www.ncbi.nlm.nih.gov/pubmed/35928921
http://dx.doi.org/10.1155/2022/9265088
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