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Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
[Purpose] The usefulness and limitations of outcome measures changes throughout functional decline of patients with Amyotrophic Lateral Sclerosis (ALS). This study aims to describe associations between outcome measures in patients with ALS over time. [Participants and Methods] Participant data was c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Society of Physical Therapy Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345750/ https://www.ncbi.nlm.nih.gov/pubmed/35937622 http://dx.doi.org/10.1589/jpts.34.532 |
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author | Sanfilippo, Michelle J. Layshock, Mary E. Keniston, Leslie |
author_facet | Sanfilippo, Michelle J. Layshock, Mary E. Keniston, Leslie |
author_sort | Sanfilippo, Michelle J. |
collection | PubMed |
description | [Purpose] The usefulness and limitations of outcome measures changes throughout functional decline of patients with Amyotrophic Lateral Sclerosis (ALS). This study aims to describe associations between outcome measures in patients with ALS over time. [Participants and Methods] Participant data was collected at a multidisciplinary ALS clinic during regular clinic visits, including gait velocity, Timed Up and Go, the ALS Functional Rating Scale-Revised, and it’s Gross Motor Subscale. [Results] All gait velocity measures were <1.2 m/sec; average Timed Up and Go was >13.5 sec. There was strong internal consistency between ALS Functional Rating Scale-Revised and its functional mobility components and a strong, significant correlation between the Timed Up and Go and the Gross Motor Subscale. [Conclusion] Patients with ALS are not community ambulators and demonstrate risk for falls. We found concurrent validity between objective and self-reported measures. The strong association between the Gross Motor Subscale and the Timed Up and Go may allow PTs to utilize the self-reported Gross Motor Subscale to predict fall risk. Clinically, when the Timed Up and Go and gait velocity are no longer appropriate due to disease progression, the Gross Motor Subscale can provide insight into functional decline. |
format | Online Article Text |
id | pubmed-9345750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Society of Physical Therapy Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-93457502022-08-05 Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis Sanfilippo, Michelle J. Layshock, Mary E. Keniston, Leslie J Phys Ther Sci Original Article [Purpose] The usefulness and limitations of outcome measures changes throughout functional decline of patients with Amyotrophic Lateral Sclerosis (ALS). This study aims to describe associations between outcome measures in patients with ALS over time. [Participants and Methods] Participant data was collected at a multidisciplinary ALS clinic during regular clinic visits, including gait velocity, Timed Up and Go, the ALS Functional Rating Scale-Revised, and it’s Gross Motor Subscale. [Results] All gait velocity measures were <1.2 m/sec; average Timed Up and Go was >13.5 sec. There was strong internal consistency between ALS Functional Rating Scale-Revised and its functional mobility components and a strong, significant correlation between the Timed Up and Go and the Gross Motor Subscale. [Conclusion] Patients with ALS are not community ambulators and demonstrate risk for falls. We found concurrent validity between objective and self-reported measures. The strong association between the Gross Motor Subscale and the Timed Up and Go may allow PTs to utilize the self-reported Gross Motor Subscale to predict fall risk. Clinically, when the Timed Up and Go and gait velocity are no longer appropriate due to disease progression, the Gross Motor Subscale can provide insight into functional decline. The Society of Physical Therapy Science 2022-08-03 2022-08 /pmc/articles/PMC9345750/ /pubmed/35937622 http://dx.doi.org/10.1589/jpts.34.532 Text en 2022©by the Society of Physical Therapy Science. Published by IPEC Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Article Sanfilippo, Michelle J. Layshock, Mary E. Keniston, Leslie Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis |
title | Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis |
title_full | Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis |
title_fullStr | Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis |
title_full_unstemmed | Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis |
title_short | Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis |
title_sort | exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345750/ https://www.ncbi.nlm.nih.gov/pubmed/35937622 http://dx.doi.org/10.1589/jpts.34.532 |
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