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Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis

[Purpose] The usefulness and limitations of outcome measures changes throughout functional decline of patients with Amyotrophic Lateral Sclerosis (ALS). This study aims to describe associations between outcome measures in patients with ALS over time. [Participants and Methods] Participant data was c...

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Autores principales: Sanfilippo, Michelle J., Layshock, Mary E., Keniston, Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society of Physical Therapy Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345750/
https://www.ncbi.nlm.nih.gov/pubmed/35937622
http://dx.doi.org/10.1589/jpts.34.532
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author Sanfilippo, Michelle J.
Layshock, Mary E.
Keniston, Leslie
author_facet Sanfilippo, Michelle J.
Layshock, Mary E.
Keniston, Leslie
author_sort Sanfilippo, Michelle J.
collection PubMed
description [Purpose] The usefulness and limitations of outcome measures changes throughout functional decline of patients with Amyotrophic Lateral Sclerosis (ALS). This study aims to describe associations between outcome measures in patients with ALS over time. [Participants and Methods] Participant data was collected at a multidisciplinary ALS clinic during regular clinic visits, including gait velocity, Timed Up and Go, the ALS Functional Rating Scale-Revised, and it’s Gross Motor Subscale. [Results] All gait velocity measures were <1.2 m/sec; average Timed Up and Go was >13.5 sec. There was strong internal consistency between ALS Functional Rating Scale-Revised and its functional mobility components and a strong, significant correlation between the Timed Up and Go and the Gross Motor Subscale. [Conclusion] Patients with ALS are not community ambulators and demonstrate risk for falls. We found concurrent validity between objective and self-reported measures. The strong association between the Gross Motor Subscale and the Timed Up and Go may allow PTs to utilize the self-reported Gross Motor Subscale to predict fall risk. Clinically, when the Timed Up and Go and gait velocity are no longer appropriate due to disease progression, the Gross Motor Subscale can provide insight into functional decline.
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spelling pubmed-93457502022-08-05 Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis Sanfilippo, Michelle J. Layshock, Mary E. Keniston, Leslie J Phys Ther Sci Original Article [Purpose] The usefulness and limitations of outcome measures changes throughout functional decline of patients with Amyotrophic Lateral Sclerosis (ALS). This study aims to describe associations between outcome measures in patients with ALS over time. [Participants and Methods] Participant data was collected at a multidisciplinary ALS clinic during regular clinic visits, including gait velocity, Timed Up and Go, the ALS Functional Rating Scale-Revised, and it’s Gross Motor Subscale. [Results] All gait velocity measures were <1.2 m/sec; average Timed Up and Go was >13.5 sec. There was strong internal consistency between ALS Functional Rating Scale-Revised and its functional mobility components and a strong, significant correlation between the Timed Up and Go and the Gross Motor Subscale. [Conclusion] Patients with ALS are not community ambulators and demonstrate risk for falls. We found concurrent validity between objective and self-reported measures. The strong association between the Gross Motor Subscale and the Timed Up and Go may allow PTs to utilize the self-reported Gross Motor Subscale to predict fall risk. Clinically, when the Timed Up and Go and gait velocity are no longer appropriate due to disease progression, the Gross Motor Subscale can provide insight into functional decline. The Society of Physical Therapy Science 2022-08-03 2022-08 /pmc/articles/PMC9345750/ /pubmed/35937622 http://dx.doi.org/10.1589/jpts.34.532 Text en 2022©by the Society of Physical Therapy Science. Published by IPEC Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Article
Sanfilippo, Michelle J.
Layshock, Mary E.
Keniston, Leslie
Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
title Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
title_full Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
title_fullStr Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
title_full_unstemmed Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
title_short Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
title_sort exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345750/
https://www.ncbi.nlm.nih.gov/pubmed/35937622
http://dx.doi.org/10.1589/jpts.34.532
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