Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation

Enzymes from pathogens often modulate host protein post-translational modifications (PTMs), facilitating survival and proliferation of pathogens. Shigella virulence factors IpaJ and IcsB induce proteolytic cleavage and lysine fatty acylation on host proteins, which cause Golgi stress and suppress in...

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Detalles Bibliográficos
Autores principales: Wang, Miao, Zhang, Yugang, Komaniecki, Garrison P., Lu, Xuan, Cao, Ji, Zhang, Mingming, Yu, Tao, Hou, Dan, Spiegelman, Nicole A., Yang, Ming, Price, Ian R., Lin, Hening
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345896/
https://www.ncbi.nlm.nih.gov/pubmed/35918380
http://dx.doi.org/10.1038/s41467-022-32227-x

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