Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma

Males exhibit higher incidence and worse prognosis for the majority of cancers, including glioblastoma (GBM). Disparate survival may be related to sex-biased responses to treatment, including radiation. Using a mouse model of GBM, we show that female cells are more sensitive to radiation, and that s...

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Detalles Bibliográficos
Autores principales: Broestl, Lauren, Warrington, Nicole M., Grandison, Lucia, Abou-Antoun, Tamara, Tung, Olivia, Shenoy, Saraswati, Tallman, Miranda M., Rhee, Gina, Yang, Wei, Sponagel, Jasmin, Yang, Lihua, Kfoury-Beaumont, Najla, Hill, Cameron M., Qanni, Sulaiman A., Mao, Diane D., Kim, Albert H., Stewart, Sheila A., Venere, Monica, Luo, Jingqin, Rubin, Joshua B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345919/
https://www.ncbi.nlm.nih.gov/pubmed/35918603
http://dx.doi.org/10.1038/s42003-022-03743-9

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