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Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?

The possibility to analyse the tumour genetic material shed in the blood is undoubtedly one of the main achievements of translational research in the latest years. In the modern clinical management of advanced non-small cell lung cancer, molecular characterisation plays an essential role. In paralle...

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Autores principales: Bonanno, Laura, Dal Maso, Alessandro, Pavan, Alberto, Zulato, Elisabetta, Calvetti, Lorenzo, Pasello, Giulia, Guarneri, Valentina, Conte, PierFranco, Indraccolo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345955/
https://www.ncbi.nlm.nih.gov/pubmed/35264788
http://dx.doi.org/10.1038/s41416-022-01777-8
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author Bonanno, Laura
Dal Maso, Alessandro
Pavan, Alberto
Zulato, Elisabetta
Calvetti, Lorenzo
Pasello, Giulia
Guarneri, Valentina
Conte, PierFranco
Indraccolo, Stefano
author_facet Bonanno, Laura
Dal Maso, Alessandro
Pavan, Alberto
Zulato, Elisabetta
Calvetti, Lorenzo
Pasello, Giulia
Guarneri, Valentina
Conte, PierFranco
Indraccolo, Stefano
author_sort Bonanno, Laura
collection PubMed
description The possibility to analyse the tumour genetic material shed in the blood is undoubtedly one of the main achievements of translational research in the latest years. In the modern clinical management of advanced non-small cell lung cancer, molecular characterisation plays an essential role. In parallel, immunotherapy is widely employed, but reliable predictive markers are not available yet. Liquid biopsy has the potential to face the two issues and to increase its role in advanced NSCLC in the next future. The aim of this review is to summarise the main clinical applications of liquid biopsy in advanced non-small cell lung cancer, underlining both its potential and limitations from a clinically driven perspective.
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spelling pubmed-93459552022-08-04 Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg? Bonanno, Laura Dal Maso, Alessandro Pavan, Alberto Zulato, Elisabetta Calvetti, Lorenzo Pasello, Giulia Guarneri, Valentina Conte, PierFranco Indraccolo, Stefano Br J Cancer Review Article The possibility to analyse the tumour genetic material shed in the blood is undoubtedly one of the main achievements of translational research in the latest years. In the modern clinical management of advanced non-small cell lung cancer, molecular characterisation plays an essential role. In parallel, immunotherapy is widely employed, but reliable predictive markers are not available yet. Liquid biopsy has the potential to face the two issues and to increase its role in advanced NSCLC in the next future. The aim of this review is to summarise the main clinical applications of liquid biopsy in advanced non-small cell lung cancer, underlining both its potential and limitations from a clinically driven perspective. Nature Publishing Group UK 2022-03-09 2022-08-01 /pmc/articles/PMC9345955/ /pubmed/35264788 http://dx.doi.org/10.1038/s41416-022-01777-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Bonanno, Laura
Dal Maso, Alessandro
Pavan, Alberto
Zulato, Elisabetta
Calvetti, Lorenzo
Pasello, Giulia
Guarneri, Valentina
Conte, PierFranco
Indraccolo, Stefano
Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
title Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
title_full Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
title_fullStr Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
title_full_unstemmed Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
title_short Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
title_sort liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345955/
https://www.ncbi.nlm.nih.gov/pubmed/35264788
http://dx.doi.org/10.1038/s41416-022-01777-8
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