BRCA mutations lead to XIAP overexpression and sensitise ovarian cancer to inhibitor of apoptosis (IAP) family inhibitors

BACKGROUND: We tested the hypothesis that inhibitor of apoptosis family (IAP) proteins may be altered in BRCA1-mutated ovarian cancers and that could affect the sensitivity to IAP inhibitors. METHODS: The levels of IAP proteins were evaluated in human cancers and cell lines. Cell lines were used to...

Descripción completa

Detalles Bibliográficos
Autores principales: Cremona, Mattia, Vandenberg, Cassandra J., Farrelly, Angela M., Madden, Stephen F., Morgan, Clare, Kalachand, Roshni, McAlpine, Jessica N., Toomey, Sinead, Huntsman, David G., Grogan, Liam, Breathnach, Oscar, Morris, Patrick, Carey, Mark S., Scott, Clare L., Hennessy, Bryan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345958/
https://www.ncbi.nlm.nih.gov/pubmed/35501389
http://dx.doi.org/10.1038/s41416-022-01823-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345958/
https://www.ncbi.nlm.nih.gov/pubmed/35501389
http://dx.doi.org/10.1038/s41416-022-01823-5

Ejemplares similares