Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia

Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been implicated in diseases such as lymphoproliferation, immunodeficiency, and autoimmunity in humans. Although auto-cleavage is indispensable for caspase-8...

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Detalles Bibliográficos
Autores principales: Li, Xiaoming, Li, Fang, Zhang, Xixi, Zhang, Haiwei, Zhao, Qun, Li, Ming, Wu, Xiaoxia, Wang, Lingxia, Liu, Jianling, Wu, Xuanhui, Ou, Yangjing, Xing, Mingyan, Zhang, Yue, Deng, Jiangshan, Wang, Xiuzhe, Luo, Yan, Li, Jinbao, Zhao, Yuwu, Zhang, Haibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345959/
https://www.ncbi.nlm.nih.gov/pubmed/35064213
http://dx.doi.org/10.1038/s41418-022-00938-9

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