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Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer

BACKGROUND: LRIG1, the founding member of the LRIG (leucine-rich repeat and immunoglobulin-like domain) family of transmembrane proteins, is a negative regulator of receptor tyrosine kinases and a tumour suppressor. Decreased LRIG1 expression is consistently observed in cancer, across diverse tumour...

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Detalles Bibliográficos
Autores principales:	Umeh-Garcia, Maxine, O’Geen, Henriette, Simion, Catalina, Gephart, Melanie Hayden, Segal, David J., Sweeney, Colleen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346006/ https://www.ncbi.nlm.nih.gov/pubmed/35440669 http://dx.doi.org/10.1038/s41416-022-01812-8

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