Chemical journey of somatic cells to pluripotency

Reprogramming somatic cells to pluripotent stem cells has revolutionized the biomedical field by providing enormous hopes and opportunities for the regeneration of tissues and organs for transplantation. Using a small molecule cocktail of epigenetic modifiers and cell signalling inhibitors, a chemic...

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Autor principal: Abbey, Deepti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346013/
https://www.ncbi.nlm.nih.gov/pubmed/35918563
http://dx.doi.org/10.1186/s13619-022-00126-7
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author Abbey, Deepti
author_facet Abbey, Deepti
author_sort Abbey, Deepti
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description Reprogramming somatic cells to pluripotent stem cells has revolutionized the biomedical field by providing enormous hopes and opportunities for the regeneration of tissues and organs for transplantation. Using a small molecule cocktail of epigenetic modifiers and cell signalling inhibitors, a chemical-based easy and controllable technique for converting human somatic cells into chemically induced pluripotent stem cells was recently reported (Guan, Nature 605:325–31, 2022). This novel approach offers well-defined, safe, simple, easy, and clinical-grade manufacturing strategies for modifying the fate of human cells required for regenerative therapeutics.
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spelling pubmed-93460132022-08-17 Chemical journey of somatic cells to pluripotency Abbey, Deepti Cell Regen Research Highlight Reprogramming somatic cells to pluripotent stem cells has revolutionized the biomedical field by providing enormous hopes and opportunities for the regeneration of tissues and organs for transplantation. Using a small molecule cocktail of epigenetic modifiers and cell signalling inhibitors, a chemical-based easy and controllable technique for converting human somatic cells into chemically induced pluripotent stem cells was recently reported (Guan, Nature 605:325–31, 2022). This novel approach offers well-defined, safe, simple, easy, and clinical-grade manufacturing strategies for modifying the fate of human cells required for regenerative therapeutics. Springer Nature Singapore 2022-08-03 /pmc/articles/PMC9346013/ /pubmed/35918563 http://dx.doi.org/10.1186/s13619-022-00126-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Highlight
Abbey, Deepti
Chemical journey of somatic cells to pluripotency
title Chemical journey of somatic cells to pluripotency
title_full Chemical journey of somatic cells to pluripotency
title_fullStr Chemical journey of somatic cells to pluripotency
title_full_unstemmed Chemical journey of somatic cells to pluripotency
title_short Chemical journey of somatic cells to pluripotency
title_sort chemical journey of somatic cells to pluripotency
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346013/
https://www.ncbi.nlm.nih.gov/pubmed/35918563
http://dx.doi.org/10.1186/s13619-022-00126-7
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