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Association of immune cell recruitment and BPD development
In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focus of many studies has been the characteristic inflammatory responses provoked by these expo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346035/ https://www.ncbi.nlm.nih.gov/pubmed/35917002 http://dx.doi.org/10.1186/s40348-022-00148-w |
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author | Heydarian, Motaharehsadat Schulz, Christian Stoeger, Tobias Hilgendorff, Anne |
author_facet | Heydarian, Motaharehsadat Schulz, Christian Stoeger, Tobias Hilgendorff, Anne |
author_sort | Heydarian, Motaharehsadat |
collection | PubMed |
description | In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focus of many studies has been the characteristic inflammatory responses provoked by these exposures. Here, we review the relationship between immaturity and prenatal conditions, as well as postnatal exposure to mechanical ventilation and oxygen toxicity, with the imbalance of pro- and anti-inflammatory regulatory networks. In these conditions, cytokine release, protease activity, and sustained presence of innate immune cells in the lung result in pathologic processes contributing to lung injury. We highlight the recruitment and function of myeloid innate immune cells, in particular, neutrophils and monocyte/macrophages in the BPD lung in human patients and animal models. We also discuss dissimilarities between the infant and adult immune system as a basis for the development of novel therapeutic strategies. |
format | Online Article Text |
id | pubmed-9346035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-93460352022-08-04 Association of immune cell recruitment and BPD development Heydarian, Motaharehsadat Schulz, Christian Stoeger, Tobias Hilgendorff, Anne Mol Cell Pediatr Review In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focus of many studies has been the characteristic inflammatory responses provoked by these exposures. Here, we review the relationship between immaturity and prenatal conditions, as well as postnatal exposure to mechanical ventilation and oxygen toxicity, with the imbalance of pro- and anti-inflammatory regulatory networks. In these conditions, cytokine release, protease activity, and sustained presence of innate immune cells in the lung result in pathologic processes contributing to lung injury. We highlight the recruitment and function of myeloid innate immune cells, in particular, neutrophils and monocyte/macrophages in the BPD lung in human patients and animal models. We also discuss dissimilarities between the infant and adult immune system as a basis for the development of novel therapeutic strategies. Springer International Publishing 2022-08-02 /pmc/articles/PMC9346035/ /pubmed/35917002 http://dx.doi.org/10.1186/s40348-022-00148-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Heydarian, Motaharehsadat Schulz, Christian Stoeger, Tobias Hilgendorff, Anne Association of immune cell recruitment and BPD development |
title | Association of immune cell recruitment and BPD development |
title_full | Association of immune cell recruitment and BPD development |
title_fullStr | Association of immune cell recruitment and BPD development |
title_full_unstemmed | Association of immune cell recruitment and BPD development |
title_short | Association of immune cell recruitment and BPD development |
title_sort | association of immune cell recruitment and bpd development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346035/ https://www.ncbi.nlm.nih.gov/pubmed/35917002 http://dx.doi.org/10.1186/s40348-022-00148-w |
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