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Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis

Antibiotic resistance of Mycobacterium tuberculosis is exclusively a consequence of chromosomal mutations. Translesion synthesis (TLS) is a widely conserved mechanism of DNA damage tolerance and mutagenesis, executed by translesion polymerases such as DinBs. In mycobacteria, DnaE2 is the only known...

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Detalles Bibliográficos
Autores principales:	Dupuy, Pierre, Ghosh, Shreya, Adefisayo, Oyindamola, Buglino, John, Shuman, Stewart, Glickman, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346131/ https://www.ncbi.nlm.nih.gov/pubmed/35918328 http://dx.doi.org/10.1038/s41467-022-32022-8

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