BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia

Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic strategy for treating various cancers. However, response rates are limited, and many patients do not achieve durable respon...

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Detalles Bibliográficos
Autores principales: Zhong, Mengjun, Gao, Rili, Zhao, Ruocong, Huang, Youxue, Chen, Cunte, Li, Kehan, Yu, Xibao, Nie, Dingrui, Chen, Zheng, Liu, Xin, Liu, Zhuandi, Chen, Shaohua, Lu, Yuhong, Yu, Zhi, Wang, Liang, Li, Peng, Zeng, Chengwu, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346138/
https://www.ncbi.nlm.nih.gov/pubmed/35918330
http://dx.doi.org/10.1038/s41419-022-05123-x

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