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Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy
BACKGROUND: This study aimed to explore the predictability of topological signatures linked to the locoregional relapse (LRR) and distant metastasis (DM) on pretreatment planning computed tomography images of stage I non‐small cell lung cancer (NSCLC) patients before treatment with stereotactic abla...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346172/ https://www.ncbi.nlm.nih.gov/pubmed/35711108 http://dx.doi.org/10.1111/1759-7714.14483 |
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author | Kodama, Takumi Arimura, Hidetaka Shirakawa, Yuko Ninomiya, Kenta Yoshitake, Tadamasa Shioyama, Yoshiyuki |
author_facet | Kodama, Takumi Arimura, Hidetaka Shirakawa, Yuko Ninomiya, Kenta Yoshitake, Tadamasa Shioyama, Yoshiyuki |
author_sort | Kodama, Takumi |
collection | PubMed |
description | BACKGROUND: This study aimed to explore the predictability of topological signatures linked to the locoregional relapse (LRR) and distant metastasis (DM) on pretreatment planning computed tomography images of stage I non‐small cell lung cancer (NSCLC) patients before treatment with stereotactic ablative radiotherapy (SABR). METHODS: We divided 125 primary stage I NSCLC patients (LRR: 34, DM: 22) into training (n = 60) and test datasets (n = 65), and the training dataset was augmented to 260 cases using a synthetic minority oversampling technique. The relapse predictabilities of the conventional wavelet‐based features (WF), topology‐based features [BF, Betti number (BN) map features; iBF, inverted BN map features], and their combined features (BWF, iBWF) were compared. The patients were stratified into high‐risk and low‐risk groups using the medians of the radiomics scores in the training dataset. RESULTS: For the LRR in the test, the iBF, iBWF, and WF showed statistically significant differences (p < 0.05), and the highest nLPC was obtained for the iBF. For the DM in the test, the iBWF showed a significant difference and the highest nLPC. CONCLUSION: The iBF indicated the potential of improving the LRR and DM prediction of stage I NSCLC patients prior to undergoing SABR. |
format | Online Article Text |
id | pubmed-9346172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-93461722022-08-05 Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy Kodama, Takumi Arimura, Hidetaka Shirakawa, Yuko Ninomiya, Kenta Yoshitake, Tadamasa Shioyama, Yoshiyuki Thorac Cancer Original Articles BACKGROUND: This study aimed to explore the predictability of topological signatures linked to the locoregional relapse (LRR) and distant metastasis (DM) on pretreatment planning computed tomography images of stage I non‐small cell lung cancer (NSCLC) patients before treatment with stereotactic ablative radiotherapy (SABR). METHODS: We divided 125 primary stage I NSCLC patients (LRR: 34, DM: 22) into training (n = 60) and test datasets (n = 65), and the training dataset was augmented to 260 cases using a synthetic minority oversampling technique. The relapse predictabilities of the conventional wavelet‐based features (WF), topology‐based features [BF, Betti number (BN) map features; iBF, inverted BN map features], and their combined features (BWF, iBWF) were compared. The patients were stratified into high‐risk and low‐risk groups using the medians of the radiomics scores in the training dataset. RESULTS: For the LRR in the test, the iBF, iBWF, and WF showed statistically significant differences (p < 0.05), and the highest nLPC was obtained for the iBF. For the DM in the test, the iBWF showed a significant difference and the highest nLPC. CONCLUSION: The iBF indicated the potential of improving the LRR and DM prediction of stage I NSCLC patients prior to undergoing SABR. John Wiley & Sons Australia, Ltd 2022-06-16 2022-08 /pmc/articles/PMC9346172/ /pubmed/35711108 http://dx.doi.org/10.1111/1759-7714.14483 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Kodama, Takumi Arimura, Hidetaka Shirakawa, Yuko Ninomiya, Kenta Yoshitake, Tadamasa Shioyama, Yoshiyuki Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy |
title | Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy |
title_full | Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy |
title_fullStr | Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy |
title_full_unstemmed | Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy |
title_short | Relapse predictability of topological signature on pretreatment planning CT images of stage I non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy |
title_sort | relapse predictability of topological signature on pretreatment planning ct images of stage i non‐small cell lung cancer patients before treatment with stereotactic ablative radiotherapy |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346172/ https://www.ncbi.nlm.nih.gov/pubmed/35711108 http://dx.doi.org/10.1111/1759-7714.14483 |
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