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Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study

BACKGROUND: Post-reperfusion syndrome (PRS) results in sudden hemodynamic instability following graft reperfusion. Although PRS is known to influence outcomes following liver transplantation, little is known regarding the effects of anesthetics on PRS. This study investigated the association between...

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Autores principales: Cho, Hye-Yeon, Lee, Ho-Jin, Kim, Won Ho, Lee, Hyung-Chul, Jung, Chul-Woo, Hong, Suk Kyun, Yang, Seong-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Anesthesiologists 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346196/
https://www.ncbi.nlm.nih.gov/pubmed/35918864
http://dx.doi.org/10.17085/apm.21104
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author Cho, Hye-Yeon
Lee, Ho-Jin
Kim, Won Ho
Lee, Hyung-Chul
Jung, Chul-Woo
Hong, Suk Kyun
Yang, Seong-Mi
author_facet Cho, Hye-Yeon
Lee, Ho-Jin
Kim, Won Ho
Lee, Hyung-Chul
Jung, Chul-Woo
Hong, Suk Kyun
Yang, Seong-Mi
author_sort Cho, Hye-Yeon
collection PubMed
description BACKGROUND: Post-reperfusion syndrome (PRS) results in sudden hemodynamic instability following graft reperfusion. Although PRS is known to influence outcomes following liver transplantation, little is known regarding the effects of anesthetics on PRS. This study investigated the association between the type of anesthetic agent and PRS in liver transplantation. METHODS: This single-center retrospective cohort study included patients who underwent liver transplantation between June 2016 and December 2019. Patients were divided into sevoflurane and propofol groups according to the anesthetic agent used. Stabilized inverse probability of treatment weighting (IPTW) analysis was performed to investigate the association between PRS identified based on blood pressure recordings and the type of anesthesia. Associations between the anesthetic agent and the duration of hypotension as well as early postoperative outcomes were also investigated. RESULTS: Data were analyzed for 398 patients, 304 (76.4%) and 94 (23.6%) of whom were anesthetized with propofol and sevoflurane, respectively. PRS developed in 40.7% of the 398 patients. Following stabilized IPTW analysis, the association with PRS was lower in the sevoflurane group than in the propofol group (odds ratio, 0.47; P = 0.018). However, there was no association between the type of anesthetic used and early postoperative outcomes. CONCLUSIONS: The association of PRS was lower in the sevoflurane group than in the propofol group. However, there was no association between the type of anesthetic and the early postoperative outcomes. Further studies are required to determine the optimal anesthetic for liver transplantation.
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spelling pubmed-93461962022-08-04 Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study Cho, Hye-Yeon Lee, Ho-Jin Kim, Won Ho Lee, Hyung-Chul Jung, Chul-Woo Hong, Suk Kyun Yang, Seong-Mi Anesth Pain Med (Seoul) Transplantation Anesthesia BACKGROUND: Post-reperfusion syndrome (PRS) results in sudden hemodynamic instability following graft reperfusion. Although PRS is known to influence outcomes following liver transplantation, little is known regarding the effects of anesthetics on PRS. This study investigated the association between the type of anesthetic agent and PRS in liver transplantation. METHODS: This single-center retrospective cohort study included patients who underwent liver transplantation between June 2016 and December 2019. Patients were divided into sevoflurane and propofol groups according to the anesthetic agent used. Stabilized inverse probability of treatment weighting (IPTW) analysis was performed to investigate the association between PRS identified based on blood pressure recordings and the type of anesthesia. Associations between the anesthetic agent and the duration of hypotension as well as early postoperative outcomes were also investigated. RESULTS: Data were analyzed for 398 patients, 304 (76.4%) and 94 (23.6%) of whom were anesthetized with propofol and sevoflurane, respectively. PRS developed in 40.7% of the 398 patients. Following stabilized IPTW analysis, the association with PRS was lower in the sevoflurane group than in the propofol group (odds ratio, 0.47; P = 0.018). However, there was no association between the type of anesthetic used and early postoperative outcomes. CONCLUSIONS: The association of PRS was lower in the sevoflurane group than in the propofol group. However, there was no association between the type of anesthetic and the early postoperative outcomes. Further studies are required to determine the optimal anesthetic for liver transplantation. Korean Society of Anesthesiologists 2022-07-31 2022-04-08 /pmc/articles/PMC9346196/ /pubmed/35918864 http://dx.doi.org/10.17085/apm.21104 Text en Copyright © the Korean Society of Anesthesiologists, 2022 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Transplantation Anesthesia
Cho, Hye-Yeon
Lee, Ho-Jin
Kim, Won Ho
Lee, Hyung-Chul
Jung, Chul-Woo
Hong, Suk Kyun
Yang, Seong-Mi
Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study
title Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study
title_full Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study
title_fullStr Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study
title_full_unstemmed Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study
title_short Influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study
title_sort influence of anesthesia type on post-reperfusion syndrome during liver transplantation: a single-center retrospective study
topic Transplantation Anesthesia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346196/
https://www.ncbi.nlm.nih.gov/pubmed/35918864
http://dx.doi.org/10.17085/apm.21104
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