The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization

The Parkinson's-disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases including Rab8 and Rab10, which enhances their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and in the intact brain, and interferes with the...

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Detalles Bibliográficos
Autores principales: Lara Ordóñez, Antonio Jesús, Fasiczka, Rachel, Fernández, Belén, Naaldijk, Yahaira, Fdez, Elena, Blanca Ramírez, Marian, Phan, Sébastien, Boassa, Daniela, Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346292/
https://www.ncbi.nlm.nih.gov/pubmed/35776681
http://dx.doi.org/10.1242/bio.059468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346292/
https://www.ncbi.nlm.nih.gov/pubmed/35776681
http://dx.doi.org/10.1242/bio.059468

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