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Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy

Heavy water is an ideal contrast agent for metabolic activity and can be adapted to a wide range of biological systems owing to its non-invasiveness, universal applicability, and cost-effectiveness. As a new type of probe, the heavy isotope of water has been widely used in the study of cell developm...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Liu, Nai-meng, Zhao, Ya-fei, Yang, Fan, Zhu, Zi-jia, Song, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346379/
https://www.ncbi.nlm.nih.gov/pubmed/35928718
http://dx.doi.org/10.7150/ijms.73150
Descripción
Sumario:Heavy water is an ideal contrast agent for metabolic activity and can be adapted to a wide range of biological systems owing to its non-invasiveness, universal applicability, and cost-effectiveness. As a new type of probe, the heavy isotope of water has been widely used in the study of cell development, metabolism, tissue homeostasis, aging, and tumor heterogeneity. Herein, we review findings supporting the applications of and research on heavy water in monitoring of bacterial metabolism, rapid detection of drug sensitivity, identification of tumor cells, precision medicine, and evaluation of skin barrier function and promote the use of heavy water as a suitable marker for the development of detection and treatment methodologies.