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Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy

Heavy water is an ideal contrast agent for metabolic activity and can be adapted to a wide range of biological systems owing to its non-invasiveness, universal applicability, and cost-effectiveness. As a new type of probe, the heavy isotope of water has been widely used in the study of cell developm...

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Autores principales: Wang, Xin, Liu, Nai-meng, Zhao, Ya-fei, Yang, Fan, Zhu, Zi-jia, Song, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346379/
https://www.ncbi.nlm.nih.gov/pubmed/35928718
http://dx.doi.org/10.7150/ijms.73150
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author Wang, Xin
Liu, Nai-meng
Zhao, Ya-fei
Yang, Fan
Zhu, Zi-jia
Song, Dong
author_facet Wang, Xin
Liu, Nai-meng
Zhao, Ya-fei
Yang, Fan
Zhu, Zi-jia
Song, Dong
author_sort Wang, Xin
collection PubMed
description Heavy water is an ideal contrast agent for metabolic activity and can be adapted to a wide range of biological systems owing to its non-invasiveness, universal applicability, and cost-effectiveness. As a new type of probe, the heavy isotope of water has been widely used in the study of cell development, metabolism, tissue homeostasis, aging, and tumor heterogeneity. Herein, we review findings supporting the applications of and research on heavy water in monitoring of bacterial metabolism, rapid detection of drug sensitivity, identification of tumor cells, precision medicine, and evaluation of skin barrier function and promote the use of heavy water as a suitable marker for the development of detection and treatment methodologies.
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spelling pubmed-93463792022-08-03 Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy Wang, Xin Liu, Nai-meng Zhao, Ya-fei Yang, Fan Zhu, Zi-jia Song, Dong Int J Med Sci Review Heavy water is an ideal contrast agent for metabolic activity and can be adapted to a wide range of biological systems owing to its non-invasiveness, universal applicability, and cost-effectiveness. As a new type of probe, the heavy isotope of water has been widely used in the study of cell development, metabolism, tissue homeostasis, aging, and tumor heterogeneity. Herein, we review findings supporting the applications of and research on heavy water in monitoring of bacterial metabolism, rapid detection of drug sensitivity, identification of tumor cells, precision medicine, and evaluation of skin barrier function and promote the use of heavy water as a suitable marker for the development of detection and treatment methodologies. Ivyspring International Publisher 2022-07-18 /pmc/articles/PMC9346379/ /pubmed/35928718 http://dx.doi.org/10.7150/ijms.73150 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Wang, Xin
Liu, Nai-meng
Zhao, Ya-fei
Yang, Fan
Zhu, Zi-jia
Song, Dong
Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy
title Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy
title_full Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy
title_fullStr Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy
title_full_unstemmed Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy
title_short Research Progress in the Medical Application of Heavy Water, Especially in the Field of D(2)O-Raman Spectroscopy
title_sort research progress in the medical application of heavy water, especially in the field of d(2)o-raman spectroscopy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346379/
https://www.ncbi.nlm.nih.gov/pubmed/35928718
http://dx.doi.org/10.7150/ijms.73150
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