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The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis

Development of vertebrate limbs and fins requires that tissue growth is directed outwards, away from the body. How such directed growth is achieved is a fascinating biological problem. For limb/fin formation and outgrowth, signaling between mesenchymal cells and the overlying epithelium is essential...

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Detalles Bibliográficos
Autores principales: Sehring, Ivonne M, Weidinger, Gilbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346477/
https://www.ncbi.nlm.nih.gov/pubmed/35836403
http://dx.doi.org/10.15252/embr.202255563
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author Sehring, Ivonne M
Weidinger, Gilbert
author_facet Sehring, Ivonne M
Weidinger, Gilbert
author_sort Sehring, Ivonne M
collection PubMed
description Development of vertebrate limbs and fins requires that tissue growth is directed outwards, away from the body. How such directed growth is achieved is a fascinating biological problem. For limb/fin formation and outgrowth, signaling between mesenchymal cells and the overlying epithelium is essential. In particular, the epithelium at the distal margin of the growing limb/fin bud, termed the apical ectodermal ridge (AER), promotes directed outgrowth of the underlying mesenchyme, e.g., by providing polarization cues for mesenchymal cell migration. Several classical signaling pathways, such as fibroblast growth factor (Fgf), hedgehog, and Wnt signaling, are involved in the regulation of the cellular events that shape the limb/fin bud (Iovine, 2007). In this issue of EMBO Reports, Carney and colleagues surprisingly find that the Slit‐Robo pathway, which is best known for its function in axon guidance, regulates the polarity of developing zebrafish fins (Mahabaleshwar et al, 2007). Intriguingly, they identify an intricate back and forth of signals between the mesenchyme and the AER. Slit ligands derived from mesenchyme act on Robo receptors in the AER to stimulate the production of sphingosine‐1‐phosphate, which then acts back on the mesenchyme to regulate cell polarity and orientation.
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spelling pubmed-93464772022-08-09 The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis Sehring, Ivonne M Weidinger, Gilbert EMBO Rep News & Views Development of vertebrate limbs and fins requires that tissue growth is directed outwards, away from the body. How such directed growth is achieved is a fascinating biological problem. For limb/fin formation and outgrowth, signaling between mesenchymal cells and the overlying epithelium is essential. In particular, the epithelium at the distal margin of the growing limb/fin bud, termed the apical ectodermal ridge (AER), promotes directed outgrowth of the underlying mesenchyme, e.g., by providing polarization cues for mesenchymal cell migration. Several classical signaling pathways, such as fibroblast growth factor (Fgf), hedgehog, and Wnt signaling, are involved in the regulation of the cellular events that shape the limb/fin bud (Iovine, 2007). In this issue of EMBO Reports, Carney and colleagues surprisingly find that the Slit‐Robo pathway, which is best known for its function in axon guidance, regulates the polarity of developing zebrafish fins (Mahabaleshwar et al, 2007). Intriguingly, they identify an intricate back and forth of signals between the mesenchyme and the AER. Slit ligands derived from mesenchyme act on Robo receptors in the AER to stimulate the production of sphingosine‐1‐phosphate, which then acts back on the mesenchyme to regulate cell polarity and orientation. John Wiley and Sons Inc. 2022-07-14 /pmc/articles/PMC9346477/ /pubmed/35836403 http://dx.doi.org/10.15252/embr.202255563 Text en © 2022 The Authors. Published under the terms of the CC BY 4.0 license. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Sehring, Ivonne M
Weidinger, Gilbert
The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis
title The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis
title_full The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis
title_fullStr The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis
title_full_unstemmed The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis
title_short The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis
title_sort fin roundabout: slit‐robo and s1p signaling coordinate fin morphogenesis
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346477/
https://www.ncbi.nlm.nih.gov/pubmed/35836403
http://dx.doi.org/10.15252/embr.202255563
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