53BP1‐mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling

DNA lesions occur across the genome and constitute a threat to cell viability; however, damage at specific genomic loci has a relatively greater impact on overall genome stability. The ribosomal RNA gene repeats (rDNA) are emerging fragile sites. Recent progress in understanding how the rDNA damage...

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Detalles Bibliográficos
Autores principales: Tsaridou, Stavroula, Velimezi, Georgia, Willenbrock, Frances, Chatzifrangkeskou, Maria, Elsayed, Waheba, Panagopoulos, Andreas, Karamitros, Dimitris, Gorgoulis, Vassilis, Lygerou, Zoi, Roukos, Vassilis, O'Neill, Eric, Pefani, Dafni Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346497/
https://www.ncbi.nlm.nih.gov/pubmed/35758159
http://dx.doi.org/10.15252/embr.202154483

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