Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death

Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1(−/−) mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activating protein shown to modulate actin cytoskeletal dynam...

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Detalles Bibliográficos
Autores principales: Shao, Andy, Lopez, Antonio Jacobo, Chen, JiaJia, Tham, Addy, Javier, Seanne, Quiroz, Alejandra, Frick, Sonia, Levine, Edward M., Lloyd, K. C. Kent, Leonard, Brian C., Murphy, Christopher J., Glaser, Thomas M., Moshiri, Ala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346516/
https://www.ncbi.nlm.nih.gov/pubmed/35758026
http://dx.doi.org/10.1242/dmm.049343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346516/
https://www.ncbi.nlm.nih.gov/pubmed/35758026
http://dx.doi.org/10.1242/dmm.049343

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