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Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death
Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1(−/−) mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activating protein shown to modulate actin cytoskeletal dynam...
Autores principales: | Shao, Andy, Lopez, Antonio Jacobo, Chen, JiaJia, Tham, Addy, Javier, Seanne, Quiroz, Alejandra, Frick, Sonia, Levine, Edward M., Lloyd, K. C. Kent, Leonard, Brian C., Murphy, Christopher J., Glaser, Thomas M., Moshiri, Ala |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346516/ https://www.ncbi.nlm.nih.gov/pubmed/35758026 http://dx.doi.org/10.1242/dmm.049343 |
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