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Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis
BACKGROUND: Although there are growing demands for stem cell-based therapy for companion animals in various diseases, a few clinical trials have been reported. Moreover, most of them are the results from only one or a few times of stem cell injection. OBJECTIVES: The aim of this study is to describe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Veterinary Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346526/ https://www.ncbi.nlm.nih.gov/pubmed/35920125 http://dx.doi.org/10.4142/jvs.22069 |
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author | Seo, Min-Gyeong Park, Seil Han, Seonyoung Kim, Ah-Young Lee, Eun-Joo Jeong, Kyu-Shik Hong, Il-Hwa |
author_facet | Seo, Min-Gyeong Park, Seil Han, Seonyoung Kim, Ah-Young Lee, Eun-Joo Jeong, Kyu-Shik Hong, Il-Hwa |
author_sort | Seo, Min-Gyeong |
collection | PubMed |
description | BACKGROUND: Although there are growing demands for stem cell-based therapy for companion animals in various diseases, a few clinical trials have been reported. Moreover, most of them are the results from only one or a few times of stem cell injection. OBJECTIVES: The aim of this study is to describe a long-term treatment with allogeneic adipose-derived stem cells (ASCs) in a dog with rheumatoid arthritis (RA), which is a rare canine disease. METHODS: The dog with RA received intravascular injection of allogeneic ASCs derived from two healthy donors once a month for 11 months. To assess therapeutic effects of ASCs, orthopedic examination and clinical evaluation was performed. Cytokines of tumor necrosis factor-α and interleukin-6 in the plasma were measured using ELISA analysis. RESULTS: Despite this repeated and long-term administration of allogeneic ASCs, there were no side effects such as immunorejection responses or cell toxicity. The orthopedic examination score for the dog decreased after ASCs treatment, and the clinical condition of the dog and owner’s satisfaction were very good CONCLUSIONS: Although ASCs has been suggested as one of the options for RA treatment because of its anti-inflammatory and immunosuppressive functions, it has never been used to treat RA in dogs. The present report describes a case of canine RA treated with allogeneic ASCs for long-term in which the dog showed clinical improvement without adverse effects. |
format | Online Article Text |
id | pubmed-9346526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-93465262022-08-11 Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis Seo, Min-Gyeong Park, Seil Han, Seonyoung Kim, Ah-Young Lee, Eun-Joo Jeong, Kyu-Shik Hong, Il-Hwa J Vet Sci Original Article BACKGROUND: Although there are growing demands for stem cell-based therapy for companion animals in various diseases, a few clinical trials have been reported. Moreover, most of them are the results from only one or a few times of stem cell injection. OBJECTIVES: The aim of this study is to describe a long-term treatment with allogeneic adipose-derived stem cells (ASCs) in a dog with rheumatoid arthritis (RA), which is a rare canine disease. METHODS: The dog with RA received intravascular injection of allogeneic ASCs derived from two healthy donors once a month for 11 months. To assess therapeutic effects of ASCs, orthopedic examination and clinical evaluation was performed. Cytokines of tumor necrosis factor-α and interleukin-6 in the plasma were measured using ELISA analysis. RESULTS: Despite this repeated and long-term administration of allogeneic ASCs, there were no side effects such as immunorejection responses or cell toxicity. The orthopedic examination score for the dog decreased after ASCs treatment, and the clinical condition of the dog and owner’s satisfaction were very good CONCLUSIONS: Although ASCs has been suggested as one of the options for RA treatment because of its anti-inflammatory and immunosuppressive functions, it has never been used to treat RA in dogs. The present report describes a case of canine RA treated with allogeneic ASCs for long-term in which the dog showed clinical improvement without adverse effects. The Korean Society of Veterinary Science 2022-07-04 /pmc/articles/PMC9346526/ /pubmed/35920125 http://dx.doi.org/10.4142/jvs.22069 Text en © 2022 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Seo, Min-Gyeong Park, Seil Han, Seonyoung Kim, Ah-Young Lee, Eun-Joo Jeong, Kyu-Shik Hong, Il-Hwa Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis |
title | Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis |
title_full | Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis |
title_fullStr | Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis |
title_full_unstemmed | Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis |
title_short | Long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis |
title_sort | long-term treatment of allogeneic adipose-derived stem cells in a dog with rheumatoid arthritis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346526/ https://www.ncbi.nlm.nih.gov/pubmed/35920125 http://dx.doi.org/10.4142/jvs.22069 |
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