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Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens

The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming. However, our knowledge of the chemosensory perception of herbal com...

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Autores principales: Kawabata, Fuminori, Murayama, Kana, Yoshida, Yuta, Liang, Ruojun, Nishimura, Shotaro, Tabata, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Poultry Science Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346593/
https://www.ncbi.nlm.nih.gov/pubmed/35974877
http://dx.doi.org/10.2141/jpsa.0210132
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author Kawabata, Fuminori
Murayama, Kana
Yoshida, Yuta
Liang, Ruojun
Nishimura, Shotaro
Tabata, Shoji
author_facet Kawabata, Fuminori
Murayama, Kana
Yoshida, Yuta
Liang, Ruojun
Nishimura, Shotaro
Tabata, Shoji
author_sort Kawabata, Fuminori
collection PubMed
description The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming. However, our knowledge of the chemosensory perception of herbal compounds in chickens is limited. Transient receptor potential ankyrin 1 (TRPA1) is involved in the sensory perception of various herbal compounds. Here, we performed calcium imaging and electrophysiological analyses using cells transiently expressing chicken TRPA1 (cTRPA1) and identified two novel cTRPA1 ligands—eugenol and thymol. In a behavioral assay, chickens responded to cTRPA1 ligands, including eugenol, thymol, cinnamaldehyde, carvacrol, and allyl isothiocyanate. These results provide evidence that chickens have a functional TRPA1 channel and chemosensory perception of various herbal compounds.
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spelling pubmed-93465932022-08-15 Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens Kawabata, Fuminori Murayama, Kana Yoshida, Yuta Liang, Ruojun Nishimura, Shotaro Tabata, Shoji J Poult Sci Research Note The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming. However, our knowledge of the chemosensory perception of herbal compounds in chickens is limited. Transient receptor potential ankyrin 1 (TRPA1) is involved in the sensory perception of various herbal compounds. Here, we performed calcium imaging and electrophysiological analyses using cells transiently expressing chicken TRPA1 (cTRPA1) and identified two novel cTRPA1 ligands—eugenol and thymol. In a behavioral assay, chickens responded to cTRPA1 ligands, including eugenol, thymol, cinnamaldehyde, carvacrol, and allyl isothiocyanate. These results provide evidence that chickens have a functional TRPA1 channel and chemosensory perception of various herbal compounds. Japan Poultry Science Association 2022-07-25 /pmc/articles/PMC9346593/ /pubmed/35974877 http://dx.doi.org/10.2141/jpsa.0210132 Text en 2022, Japan Poultry Science Association. https://creativecommons.org/licenses/by-nc-sa/4.0/The Journal of Poultry Science is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Note
Kawabata, Fuminori
Murayama, Kana
Yoshida, Yuta
Liang, Ruojun
Nishimura, Shotaro
Tabata, Shoji
Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens
title Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens
title_full Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens
title_fullStr Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens
title_full_unstemmed Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens
title_short Identification of Ligands for Chicken Transient Receptor Potential Ankyrin 1 Channel and Chemosensory Perception of Herbal Compounds in Chickens
title_sort identification of ligands for chicken transient receptor potential ankyrin 1 channel and chemosensory perception of herbal compounds in chickens
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346593/
https://www.ncbi.nlm.nih.gov/pubmed/35974877
http://dx.doi.org/10.2141/jpsa.0210132
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