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Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment
Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors have poor 5-year survival for patients. Gliomas are principally characterized by rapid diffusion as well as high levels of cellular heterogeneity. However, to date, the exact pathogenic mechanisms, contributing...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347108/ https://www.ncbi.nlm.nih.gov/pubmed/35922753 http://dx.doi.org/10.1186/s11658-022-00354-4 |
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author | Mafi, Alireza Rahmati, Atefe Babaei Aghdam, Zahra Salami, Raziyeh Salami, Marziyeh Vakili, Omid Aghadavod, Esmat |
author_facet | Mafi, Alireza Rahmati, Atefe Babaei Aghdam, Zahra Salami, Raziyeh Salami, Marziyeh Vakili, Omid Aghadavod, Esmat |
author_sort | Mafi, Alireza |
collection | PubMed |
description | Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors have poor 5-year survival for patients. Gliomas are principally characterized by rapid diffusion as well as high levels of cellular heterogeneity. However, to date, the exact pathogenic mechanisms, contributing to gliomas remain ambiguous. MicroRNAs (miRNAs), as small noncoding RNAs of about 20 nucleotides in length, are known as chief modulators of different biological processes at both transcriptional and posttranscriptional levels. More recently, it has been revealed that these noncoding RNA molecules have essential roles in tumorigenesis and progression of multiple cancers, including gliomas. Interestingly, miRNAs are able to modulate diverse cancer-related processes such as cell proliferation and apoptosis, invasion and migration, differentiation and stemness, angiogenesis, and drug resistance; thus, impaired miRNAs may result in deterioration of gliomas. Additionally, miRNAs can be secreted into cerebrospinal fluid (CSF), as well as the bloodstream, and transported between normal and tumor cells freely or by exosomes, converting them into potential diagnostic and/or prognostic biomarkers for gliomas. They would also be great therapeutic agents, especially if they could cross the blood–brain barrier (BBB). Accordingly, in the current review, the contribution of miRNAs to glioma pathogenesis is first discussed, then their glioma-related diagnostic/prognostic and therapeutic potential is highlighted briefly. |
format | Online Article Text |
id | pubmed-9347108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93471082022-08-04 Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment Mafi, Alireza Rahmati, Atefe Babaei Aghdam, Zahra Salami, Raziyeh Salami, Marziyeh Vakili, Omid Aghadavod, Esmat Cell Mol Biol Lett Review Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors have poor 5-year survival for patients. Gliomas are principally characterized by rapid diffusion as well as high levels of cellular heterogeneity. However, to date, the exact pathogenic mechanisms, contributing to gliomas remain ambiguous. MicroRNAs (miRNAs), as small noncoding RNAs of about 20 nucleotides in length, are known as chief modulators of different biological processes at both transcriptional and posttranscriptional levels. More recently, it has been revealed that these noncoding RNA molecules have essential roles in tumorigenesis and progression of multiple cancers, including gliomas. Interestingly, miRNAs are able to modulate diverse cancer-related processes such as cell proliferation and apoptosis, invasion and migration, differentiation and stemness, angiogenesis, and drug resistance; thus, impaired miRNAs may result in deterioration of gliomas. Additionally, miRNAs can be secreted into cerebrospinal fluid (CSF), as well as the bloodstream, and transported between normal and tumor cells freely or by exosomes, converting them into potential diagnostic and/or prognostic biomarkers for gliomas. They would also be great therapeutic agents, especially if they could cross the blood–brain barrier (BBB). Accordingly, in the current review, the contribution of miRNAs to glioma pathogenesis is first discussed, then their glioma-related diagnostic/prognostic and therapeutic potential is highlighted briefly. BioMed Central 2022-08-03 /pmc/articles/PMC9347108/ /pubmed/35922753 http://dx.doi.org/10.1186/s11658-022-00354-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Mafi, Alireza Rahmati, Atefe Babaei Aghdam, Zahra Salami, Raziyeh Salami, Marziyeh Vakili, Omid Aghadavod, Esmat Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment |
title | Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment |
title_full | Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment |
title_fullStr | Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment |
title_full_unstemmed | Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment |
title_short | Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment |
title_sort | recent insights into the microrna-dependent modulation of gliomas from pathogenesis to diagnosis and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347108/ https://www.ncbi.nlm.nih.gov/pubmed/35922753 http://dx.doi.org/10.1186/s11658-022-00354-4 |
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