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Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease

BACKGROUND: NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extracellular Aβ fibrils but also inhibits the activation of NRLP3 inflammasome. Here,...

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Detalles Bibliográficos
Autores principales:	Zhou, Xiao-Gang, Qiu, Wen-Qiao, Yu, Lu, Pan, Rong, Teng, Jin-Feng, Sang, Zhi-Pei, Law, Betty Yuen-Kwan, Zhao, Ya, Zhang, Li, Yan, Lu, Tang, Yong, Sun, Xiao-Lei, Wong, Vincent Kam Wai, Yu, Chong-Lin, Wu, Jian-Ming, Qin, Da-Lian, Wu, An-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347127/ https://www.ncbi.nlm.nih.gov/pubmed/35918778 http://dx.doi.org/10.1186/s41232-022-00209-7

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