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Bias and inconsistency in the estimation of tumour mutation burden

BACKGROUND: Tumour mutation burden (TMB), defined as the number of somatic mutations per megabase within the sequenced region in the tumour sample, has been used as a biomarker for predicting response to immune therapy. Several studies have been conducted to assess the utility of TMB for various can...

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Detalles Bibliográficos
Autores principales:	Makrooni, Mohammad A., O’Sullivan, Brian, Seoighe, Cathal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347149/ https://www.ncbi.nlm.nih.gov/pubmed/35918650 http://dx.doi.org/10.1186/s12885-022-09897-3

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