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Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations

Herein we describe an efficient, simple, and precise micelle-mediated microextraction strategy based on the aggregation behavior of surface-active ionic liquids (SAILs) for the preconcentration and determination of cobalt ions in pharmaceutical preparations. Unlike the commonly used hydrophobic ioni...

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Autores principales: Bamdad, Farzad, Habibi, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347226/
https://www.ncbi.nlm.nih.gov/pubmed/35937559
http://dx.doi.org/10.5812/ijpr-127043
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author Bamdad, Farzad
Habibi, Zahra
author_facet Bamdad, Farzad
Habibi, Zahra
author_sort Bamdad, Farzad
collection PubMed
description Herein we describe an efficient, simple, and precise micelle-mediated microextraction strategy based on the aggregation behavior of surface-active ionic liquids (SAILs) for the preconcentration and determination of cobalt ions in pharmaceutical preparations. Unlike the commonly used hydrophobic ionic liquids in IL-based microextraction methods, a water-soluble surface-active ionic liquid [1-hexadecyl 3-methylimidazolium chloride (C(16)MeImCl)] was used. A modified cloud point extraction (CPE) procedure based on the C(16)MeImCl-Triton X-114 mixed micellar system was proposed as an efficient extracting phase. A comparison of the analytical features of the extraction process with and without SAILs revealed the benefits of the proposed method. Advantages such as a wider linear range, lower detection limit, higher reproducibility, and improved extraction efficiency highlighted the proposed method over the conventional CPE method. These attractive specifications are due to the higher extraction efficiencies achieved in the presence of the SAIL and its favorable effects at the phase separation stage. Various parameters affecting the extraction efficiency were optimized by univariate and multivariate (Box-Behnken design) approaches. The calibration curve was obtained in the optimal experimental conditions with a linear range from 0.01 to 5.5 mg L(-1) of cobalt ion concentration (R = 0.9992) and a detection limit of about 0.005 mg L(-1). The RSD% for 10 replicate determinations of 1.0 mg L(-1) Co was 0.9%. The proposed method was successfully applied to determine cobalt ions in vitamin B(12) ampoules and tablets.
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spelling pubmed-93472262022-08-05 Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations Bamdad, Farzad Habibi, Zahra Iran J Pharm Res Research Article Herein we describe an efficient, simple, and precise micelle-mediated microextraction strategy based on the aggregation behavior of surface-active ionic liquids (SAILs) for the preconcentration and determination of cobalt ions in pharmaceutical preparations. Unlike the commonly used hydrophobic ionic liquids in IL-based microextraction methods, a water-soluble surface-active ionic liquid [1-hexadecyl 3-methylimidazolium chloride (C(16)MeImCl)] was used. A modified cloud point extraction (CPE) procedure based on the C(16)MeImCl-Triton X-114 mixed micellar system was proposed as an efficient extracting phase. A comparison of the analytical features of the extraction process with and without SAILs revealed the benefits of the proposed method. Advantages such as a wider linear range, lower detection limit, higher reproducibility, and improved extraction efficiency highlighted the proposed method over the conventional CPE method. These attractive specifications are due to the higher extraction efficiencies achieved in the presence of the SAIL and its favorable effects at the phase separation stage. Various parameters affecting the extraction efficiency were optimized by univariate and multivariate (Box-Behnken design) approaches. The calibration curve was obtained in the optimal experimental conditions with a linear range from 0.01 to 5.5 mg L(-1) of cobalt ion concentration (R = 0.9992) and a detection limit of about 0.005 mg L(-1). The RSD% for 10 replicate determinations of 1.0 mg L(-1) Co was 0.9%. The proposed method was successfully applied to determine cobalt ions in vitamin B(12) ampoules and tablets. Brieflands 2022-05-17 /pmc/articles/PMC9347226/ /pubmed/35937559 http://dx.doi.org/10.5812/ijpr-127043 Text en Copyright © 2022, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Bamdad, Farzad
Habibi, Zahra
Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations
title Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations
title_full Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations
title_fullStr Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations
title_full_unstemmed Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations
title_short Surface-Active Ionic Liquid-Assisted Cloud Point Extraction for Pre-Concentration and Determination of Cobalt Ions in Pharmaceutical Preparations
title_sort surface-active ionic liquid-assisted cloud point extraction for pre-concentration and determination of cobalt ions in pharmaceutical preparations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347226/
https://www.ncbi.nlm.nih.gov/pubmed/35937559
http://dx.doi.org/10.5812/ijpr-127043
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