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Coronin-1 levels in patients with tuberculosis

BACKGROUND & OBJECTIVES: Despite advances in diagnostics and therapeutics, tuberculosis (TB) is widely prevalent and contributes to a significant burden of illness in both developing and developed nations. The present study was aimed to assess the role of coronin in TB patients and healthy contr...

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Autores principales: Sinha, Sanjeev, Gupta, Gaurav, Biswas, Sagnik, Gupta, Kartik, Singh, P.P., Jain, Rahul, Sharma, S.K., Das, Bimal K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347245/
https://www.ncbi.nlm.nih.gov/pubmed/35662092
http://dx.doi.org/10.4103/ijmr.IJMR_4343_20
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author Sinha, Sanjeev
Gupta, Gaurav
Biswas, Sagnik
Gupta, Kartik
Singh, P.P.
Jain, Rahul
Sharma, S.K.
Das, Bimal K.
author_facet Sinha, Sanjeev
Gupta, Gaurav
Biswas, Sagnik
Gupta, Kartik
Singh, P.P.
Jain, Rahul
Sharma, S.K.
Das, Bimal K.
author_sort Sinha, Sanjeev
collection PubMed
description BACKGROUND & OBJECTIVES: Despite advances in diagnostics and therapeutics, tuberculosis (TB) is widely prevalent and contributes to a significant burden of illness in both developing and developed nations. The present study was aimed to assess the role of coronin in TB patients and healthy controls. Coronin is a leucocyte-specific protein that is actively recruited in mycobacterial phagolysosomes, where it inhibits lysosomal delivery of Mycobacterium by activating a calcium-dependent phosphatase-calcineurin. METHODS: In the study, 100 newly diagnosed cases of TB (pulmonary and extra-pulmonary) and healthy controls were prospectively enrolled over one year and the levels of coronin-1a in these patients and controls were measured by quantitative PCR (qPCR). RESULTS: A total of 100 TB patients and 100 healthy individuals as controls were assessed. There were 59 patients with extra-pulmonary TB (EPTB) and 41 of pulmonary TB (PTB). In 47 per cent of patients, corroborative histopathological evidence of TB was also available. Significantly higher values of coronin-1a were observed in TB patients (19.94±2.61) than in healthy controls (16.09±1.91) (P<0.001). INTERPRETATION & CONCLUSIONS: Coronin 1a appears to play an important role in the TB disease pathophysiology and agents developed against coronin may have a role in the treatment of TB. Further studies are required to assess if coronin-1a levels are elevated in non-tubercular infective a etiologies and whether these can be a potential drug target in patients with TB.
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spelling pubmed-93472452022-08-04 Coronin-1 levels in patients with tuberculosis Sinha, Sanjeev Gupta, Gaurav Biswas, Sagnik Gupta, Kartik Singh, P.P. Jain, Rahul Sharma, S.K. Das, Bimal K. Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Despite advances in diagnostics and therapeutics, tuberculosis (TB) is widely prevalent and contributes to a significant burden of illness in both developing and developed nations. The present study was aimed to assess the role of coronin in TB patients and healthy controls. Coronin is a leucocyte-specific protein that is actively recruited in mycobacterial phagolysosomes, where it inhibits lysosomal delivery of Mycobacterium by activating a calcium-dependent phosphatase-calcineurin. METHODS: In the study, 100 newly diagnosed cases of TB (pulmonary and extra-pulmonary) and healthy controls were prospectively enrolled over one year and the levels of coronin-1a in these patients and controls were measured by quantitative PCR (qPCR). RESULTS: A total of 100 TB patients and 100 healthy individuals as controls were assessed. There were 59 patients with extra-pulmonary TB (EPTB) and 41 of pulmonary TB (PTB). In 47 per cent of patients, corroborative histopathological evidence of TB was also available. Significantly higher values of coronin-1a were observed in TB patients (19.94±2.61) than in healthy controls (16.09±1.91) (P<0.001). INTERPRETATION & CONCLUSIONS: Coronin 1a appears to play an important role in the TB disease pathophysiology and agents developed against coronin may have a role in the treatment of TB. Further studies are required to assess if coronin-1a levels are elevated in non-tubercular infective a etiologies and whether these can be a potential drug target in patients with TB. Wolters Kluwer - Medknow 2021-12 /pmc/articles/PMC9347245/ /pubmed/35662092 http://dx.doi.org/10.4103/ijmr.IJMR_4343_20 Text en Copyright: © 2022 Indian Journal of Medical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sinha, Sanjeev
Gupta, Gaurav
Biswas, Sagnik
Gupta, Kartik
Singh, P.P.
Jain, Rahul
Sharma, S.K.
Das, Bimal K.
Coronin-1 levels in patients with tuberculosis
title Coronin-1 levels in patients with tuberculosis
title_full Coronin-1 levels in patients with tuberculosis
title_fullStr Coronin-1 levels in patients with tuberculosis
title_full_unstemmed Coronin-1 levels in patients with tuberculosis
title_short Coronin-1 levels in patients with tuberculosis
title_sort coronin-1 levels in patients with tuberculosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347245/
https://www.ncbi.nlm.nih.gov/pubmed/35662092
http://dx.doi.org/10.4103/ijmr.IJMR_4343_20
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