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Synthesis of the l- and d-SH2 domain of the leukaemia oncogene Bcr-Abl

The d- and l-versions of the Bcr-Abl SH2 domain (12.7 kDa) were synthesized. Key optimizations included pseudoproline incorporation, N-terminal hydrophilic tail addition and mild N-acetoxy succinimide acetylation. Their folding and activity are as for the recombinant protein. Our results will enable...

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Detalles Bibliográficos
Autores principales:	Schmidt, Nina, Abendroth, Frank, Vázquez, Olalla, Hantschel, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347351/ https://www.ncbi.nlm.nih.gov/pubmed/35975004 http://dx.doi.org/10.1039/d2cb00108j

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