Mutant polymerases capable of 2′ fluoro-modified nucleic acid synthesis and amplification with improved accuracy

Nonnatural nucleic acids (xeno nucleic acids, XNA) can possess several useful properties such as expanded reactivity and nuclease resistance, which can enhance the utility of DNA as a biotechnological tool. Native DNA polymerases are unable to synthesize XNA, so, in recent years mutant XNA polymeras...

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Detalles Bibliográficos
Autores principales: Christensen, Trevor A., Lee, Kristi Y., Gottlieb, Simone Z. P., Carrier, Mikayla B., Leconte, Aaron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347352/
https://www.ncbi.nlm.nih.gov/pubmed/35975008
http://dx.doi.org/10.1039/d2cb00064d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347352/
https://www.ncbi.nlm.nih.gov/pubmed/35975008
http://dx.doi.org/10.1039/d2cb00064d

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