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Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors
Polyomaviruses are a family of ubiquitous double-stranded DNA viruses many of which are human pathogens. These include BK polyomavirus which causes severe urinary tract infection in immunocompromised patients and Merkel cell polyomavirus associated with aggressive cancers. The small genome of polyom...
Autores principales: | Osipov, Evgenii M., Munawar, Ali H., Beelen, Steven, Fearon, Daren, Douangamath, Alice, Wild, Conor, Weeks, Stephen D., Van Aerschot, Arthur, von Delft, Frank, Strelkov, Sergei V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347357/ https://www.ncbi.nlm.nih.gov/pubmed/35974998 http://dx.doi.org/10.1039/d2cb00052k |
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