A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape

The identification of a novel class of shark‐derived single domain antibodies, named vnarbodies that show picomolar affinities binding to the receptor binding domain (RBD) of Wuhan and Alpha, Beta, Kappa, Delta, Delta‐plus, and Lambda variants, is reported. Vnarbody 20G6 and 17F6 have broad neutrali...

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Detalles Bibliográficos
Autores principales: Feng, Bo, Chen, Zhilong, Sun, Jing, Xu, Tingting, Wang, Qian, Yi, Haisu, Niu, Xuefeng, Zhu, Jiabin, Fan, Mengzhu, Hou, Ruitian, Shao, Ying, Huang, Sihui, Li, Cuiyun, Hu, Peiyu, Zheng, Pingqian, He, Ping, Luo, Jia, Yan, Qihong, Xiong, Xiaoli, Liu, Jinsong, Zhao, Jincun, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347709/
https://www.ncbi.nlm.nih.gov/pubmed/35583124
http://dx.doi.org/10.1002/smtd.202200387

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