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Oridonin Inhibits SARS‐CoV‐2 by Targeting Its 3C‐Like Protease

Oridonin Inhibits SARS‐CoV‐2 Oridonin, a natural product extracted from Rabdosia rubescens, possesses a wide range of pharmacological properties, including anti‐inflammatory, anti‐cancer, anti‐microbial, neuroprotection, immunoregulation, etc. In article number 2100124, Baisen Zhong, Litao Sun, and...

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Detalles Bibliográficos
Autores principales: Zhong, Baisen, Peng, Weiyu, Du, Shan, Chen, Bingyi, Feng, Yajuan, Hu, Xinfeng, Lai, Qi, Liu, Shujie, Zhou, Zhong-Wei, Fang, Pengfei, Wu, Yan, Gao, Feng, Zhou, Huihao, Sun, Litao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347789/
https://www.ncbi.nlm.nih.gov/pubmed/35942318
http://dx.doi.org/10.1002/smsc.202270012
Descripción
Sumario:Oridonin Inhibits SARS‐CoV‐2 Oridonin, a natural product extracted from Rabdosia rubescens, possesses a wide range of pharmacological properties, including anti‐inflammatory, anti‐cancer, anti‐microbial, neuroprotection, immunoregulation, etc. In article number 2100124, Baisen Zhong, Litao Sun, and co‐workers demonstrate that Oridonin targets the SARS‐CoV‐2 3CL protease by covalently binding to cysteine145 in its active pocket to exert an anti‐SARS‐CoV‐2 effect, which provides a novel candidate for the treatment of COVID‐19. [Image: see text]