Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic

An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of “free” (unbound to the dosed anti-IL-11 therapeutic...

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Detalles Bibliográficos
Autores principales: Myzithras, Maria, Lin, Siqi, Radden, Legairre, Hess Kenny, Cynthia, Cai, Zheng, MacDonald, Angus, Binetti, Ralph, Marlow, Michael, Fracasso, Paul, Gibson, Glenn, Bartlett, Christina, Hawkins, Julie, Hansel, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348130/
https://www.ncbi.nlm.nih.gov/pubmed/35916739
http://dx.doi.org/10.1080/19420862.2022.2104153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348130/
https://www.ncbi.nlm.nih.gov/pubmed/35916739
http://dx.doi.org/10.1080/19420862.2022.2104153

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