Cargando…

Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic

An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of “free” (unbound to the dosed anti-IL-11 therapeutic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Myzithras, Maria, Lin, Siqi, Radden, Legairre, Hess Kenny, Cynthia, Cai, Zheng, MacDonald, Angus, Binetti, Ralph, Marlow, Michael, Fracasso, Paul, Gibson, Glenn, Bartlett, Christina, Hawkins, Julie, Hansel, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348130/ https://www.ncbi.nlm.nih.gov/pubmed/35916739 http://dx.doi.org/10.1080/19420862.2022.2104153

Ejemplares similares

The wooly mutation (wly) on mouse chromosome 11 is associated with a genetic defect in Fam83g
por: Radden, Legairre A, et al.
Publicado: (2013)

IL-11 and IL-11Rα immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development
por: Dimitriadis, E, et al.
Publicado: (2003)

IL-11 in multiple sclerosis
por: Zhang, Xin, et al.
Publicado: (2015)

Effects of IL-11/IL-11 Receptor Alpha on Proliferation and Steroidogenesis in Ovarian Granulosa Cells of Dairy Cows
por: Wu, Hanxiao, et al.
Publicado: (2023)

The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine
por: Dong, Bingzi, et al.
Publicado: (2023)

Downregulation of macrophage IL-12 production by tumor-derived IL-11
por: Torroella, M, et al.
Publicado: (2001)

Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases
por: Maroni, Paola, et al.
Publicado: (2021)

Targeting IL-11 signaling in colon cancer
por: Ernst, Matthias, et al.
Publicado: (2013)

Roles and mechanism of IL-11 in vascular diseases
por: Wu, Jiacheng, et al.
Publicado: (2023)

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
por: Ng, Benjamin, et al.
Publicado: (2021)

IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts
por: Adami, Eleonora, et al.
Publicado: (2021)

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues
por: Widjaja, Anissa A., et al.
Publicado: (2022)

Zac1 regulates IL-11 expression in osteoarthritis
por: Kuo, Chun-Lin, et al.
Publicado: (2018)

IL-11 drives postsurgical hepatocellular carcinoma recurrence
por: Lauko, Adam, et al.
Publicado: (2019)

IL11 activates the placental inflammasome to drive preeclampsia
por: Menkhorst, Ellen, et al.
Publicado: (2023)

OR11-004 - IL-1, IL-18 and cell death in NLRP3 driven disease
por: Broderick, L, et al.
Publicado: (2013)

YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11
por: Wang, Jing, et al.
Publicado: (2019)

Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway
por: Tao, Leilei, et al.
Publicado: (2016)

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
por: Schwerd, Tobias, et al.
Publicado: (2020)

IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome
por: Ng, Benjamin, et al.
Publicado: (2023)

Mechanistic understanding of human SLFN11
por: Metzner, Felix J., et al.
Publicado: (2022)

Characterisation and expression analysis of the Atlantic halibut (Hippoglossus hippoglossus L.) cytokines: IL-1β, IL-6, IL-11, IL-12β and IFNγ
por: Øvergård, Aina-Cathrine, et al.
Publicado: (2011)

IL-3 and CSF-1 Interact to Promote Generation of CD11c(+) IL-10-Producing Macrophages
por: Sheng, Kuo-Ching, et al.
Publicado: (2014)

IL-17 and IL-11 GCF Levels in Aggressive and Chronic Periodontitis Patients: Relation to PCR Bacterial Detection
por: Shaker, Olfat G., et al.
Publicado: (2012)

Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction
por: Lu, Liqin, et al.
Publicado: (2021)

Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer
por: Chen, Zheng, et al.
Publicado: (2023)

[(11)C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy
por: Passamonti, Luca, et al.
Publicado: (2018)

ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro
por: Yu, Dandan, et al.
Publicado: (2015)

BDNF and IL-8, But Not UCHL-1 and IL-11, Are Markers of Brain Injury in Children Caused by Mild Head Trauma
por: Tylicka, Marzena, et al.
Publicado: (2020)

HepG2 hepatocytes express IFN-γ, TNF-α, TGF-β, M-CSF, oncostatin-M, ICAM-1, IL-4, IL-5, IL-7, IL-10, IL-11, IL-12 and IL-6 receptor genes in vitro
por: Russwurm, S, et al.
Publicado: (1998)

OR11-005 - Mast cells respond to pathogen signals with IL-1ß
por: Kraas, L, et al.
Publicado: (2013)

Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11
por: Cheng, Man, et al.
Publicado: (2005)

IL‐11 in cardiac and renal fibrosis: Late to the party but a central player
por: Corden, Benjamin, et al.
Publicado: (2020)

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts
por: Widjaja, Anissa A., et al.
Publicado: (2021)

IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
por: Milara, Javier, et al.
Publicado: (2022)

Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction
por: Sweeney, Mark, et al.
Publicado: (2023)

Gingival Fibroblasts Are Sensitive to Oral Cell Lysates Indicated by Their IL11 Expression
por: Panahipour, Layla, et al.
Publicado: (2023)

An in vivo (11)C‐PK PET study of microglia activation in Fatal Familial Insomnia
por: Iaccarino, Leonardo, et al.
Publicado: (2017)

Abnormal neuroinflammation in fibromyalgia and CRPS using [(11)C]-(R)-PK11195 PET
por: Seo, Seongho, et al.
Publicado: (2021)

Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury
por: Cho, Newton, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ovar1klu5hdm9esegssgnvjpuh