Cargando…

Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant

Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID‐19) and emerging variants. The optimal prophylactic vaccine strategy for this cohort is not defined. T cell‐mediated immunity is a critical component of graft...

Descripción completa

Detalles Bibliográficos
Autores principales: Murray, Sam M., Barbanti, Maria, Campbell, Cori, Brown, Anthony, Chen, Lucia, Dhanapal, Jay, Tseu, Bing, Pervaiz, Omer, Peters, Louis, Springett, Sally, Danby, Robert, Adele, Sandra, Phillips, Eloise, Malone, Tom, Amini, Ali, Stafford, Lizzie, Deeks, Alexandra S., Dunachie, Susanna, Klenerman, Paul, Peniket, Andrew, Barnes, Eleanor, Kesavan, Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348196/
https://www.ncbi.nlm.nih.gov/pubmed/35655410
http://dx.doi.org/10.1111/bjh.18312
_version_ 1784761908934475776
author Murray, Sam M.
Barbanti, Maria
Campbell, Cori
Brown, Anthony
Chen, Lucia
Dhanapal, Jay
Tseu, Bing
Pervaiz, Omer
Peters, Louis
Springett, Sally
Danby, Robert
Adele, Sandra
Phillips, Eloise
Malone, Tom
Amini, Ali
Stafford, Lizzie
Deeks, Alexandra S.
Dunachie, Susanna
Klenerman, Paul
Peniket, Andrew
Barnes, Eleanor
Kesavan, Murali
author_facet Murray, Sam M.
Barbanti, Maria
Campbell, Cori
Brown, Anthony
Chen, Lucia
Dhanapal, Jay
Tseu, Bing
Pervaiz, Omer
Peters, Louis
Springett, Sally
Danby, Robert
Adele, Sandra
Phillips, Eloise
Malone, Tom
Amini, Ali
Stafford, Lizzie
Deeks, Alexandra S.
Dunachie, Susanna
Klenerman, Paul
Peniket, Andrew
Barnes, Eleanor
Kesavan, Murali
author_sort Murray, Sam M.
collection PubMed
description Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID‐19) and emerging variants. The optimal prophylactic vaccine strategy for this cohort is not defined. T cell‐mediated immunity is a critical component of graft‐versus‐tumour effect and in determining vaccine immunogenicity. Using validated anti‐spike (S) immunoglobulin G (IgG) and S‐specific interferon‐gamma enzyme‐linked immunospot (IFNγ‐ELIspot) assays we analysed response to a two‐dose vaccination schedule (either BNT162b2 or ChAdOx1) in 33 HSCT recipients at ≤2 years from transplant, alongside vaccine‐matched healthy controls (HCs). After two vaccines, infection‐naïve HSCT recipients had a significantly lower rate of seroconversion compared to infection‐naïve HCs (25/32 HSCT vs. 39/39 HCs no responders) and had lower S‐specific T‐cell responses. The HSCT recipients who received BNT162b2 had a higher rate of seroconversion compared to ChAdOx1 (89% vs. 74%) and significantly higher anti‐S IgG titres (p = 0.022). S‐specific T‐cell responses were seen after one vaccine in HCs and HSCT recipients. However, two vaccines enhanced S‐specific T‐cell responses in HCs but not in the majority of HSCT recipients. These data demonstrate limited immunogenicity of two‐dose vaccination strategies in HSCT recipients, bolstering evidence of the need for additional boosters and/or alternative prophylactic measures in this group.
format Online
Article
Text
id pubmed-9348196
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-93481962022-08-04 Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant Murray, Sam M. Barbanti, Maria Campbell, Cori Brown, Anthony Chen, Lucia Dhanapal, Jay Tseu, Bing Pervaiz, Omer Peters, Louis Springett, Sally Danby, Robert Adele, Sandra Phillips, Eloise Malone, Tom Amini, Ali Stafford, Lizzie Deeks, Alexandra S. Dunachie, Susanna Klenerman, Paul Peniket, Andrew Barnes, Eleanor Kesavan, Murali Br J Haematol Original Papers Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID‐19) and emerging variants. The optimal prophylactic vaccine strategy for this cohort is not defined. T cell‐mediated immunity is a critical component of graft‐versus‐tumour effect and in determining vaccine immunogenicity. Using validated anti‐spike (S) immunoglobulin G (IgG) and S‐specific interferon‐gamma enzyme‐linked immunospot (IFNγ‐ELIspot) assays we analysed response to a two‐dose vaccination schedule (either BNT162b2 or ChAdOx1) in 33 HSCT recipients at ≤2 years from transplant, alongside vaccine‐matched healthy controls (HCs). After two vaccines, infection‐naïve HSCT recipients had a significantly lower rate of seroconversion compared to infection‐naïve HCs (25/32 HSCT vs. 39/39 HCs no responders) and had lower S‐specific T‐cell responses. The HSCT recipients who received BNT162b2 had a higher rate of seroconversion compared to ChAdOx1 (89% vs. 74%) and significantly higher anti‐S IgG titres (p = 0.022). S‐specific T‐cell responses were seen after one vaccine in HCs and HSCT recipients. However, two vaccines enhanced S‐specific T‐cell responses in HCs but not in the majority of HSCT recipients. These data demonstrate limited immunogenicity of two‐dose vaccination strategies in HSCT recipients, bolstering evidence of the need for additional boosters and/or alternative prophylactic measures in this group. John Wiley and Sons Inc. 2022-06-22 /pmc/articles/PMC9348196/ /pubmed/35655410 http://dx.doi.org/10.1111/bjh.18312 Text en © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Papers
Murray, Sam M.
Barbanti, Maria
Campbell, Cori
Brown, Anthony
Chen, Lucia
Dhanapal, Jay
Tseu, Bing
Pervaiz, Omer
Peters, Louis
Springett, Sally
Danby, Robert
Adele, Sandra
Phillips, Eloise
Malone, Tom
Amini, Ali
Stafford, Lizzie
Deeks, Alexandra S.
Dunachie, Susanna
Klenerman, Paul
Peniket, Andrew
Barnes, Eleanor
Kesavan, Murali
Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
title Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
title_full Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
title_fullStr Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
title_full_unstemmed Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
title_short Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
title_sort impaired humoral and cellular response to primary covid‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348196/
https://www.ncbi.nlm.nih.gov/pubmed/35655410
http://dx.doi.org/10.1111/bjh.18312
work_keys_str_mv AT murraysamm impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT barbantimaria impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT campbellcori impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT brownanthony impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT chenlucia impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT dhanapaljay impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT tseubing impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT pervaizomer impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT peterslouis impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT springettsally impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT danbyrobert impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT adelesandra impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT phillipseloise impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT malonetom impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT aminiali impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT staffordlizzie impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT deeksalexandras impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT dunachiesusanna impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT klenermanpaul impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT peniketandrew impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT barneseleanor impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant
AT kesavanmurali impairedhumoralandcellularresponsetoprimarycovid19vaccinationinpatientslessthan2yearsafterallogeneicbonemarrowtransplant