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Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant
Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID‐19) and emerging variants. The optimal prophylactic vaccine strategy for this cohort is not defined. T cell‐mediated immunity is a critical component of graft...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348196/ https://www.ncbi.nlm.nih.gov/pubmed/35655410 http://dx.doi.org/10.1111/bjh.18312 |
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author | Murray, Sam M. Barbanti, Maria Campbell, Cori Brown, Anthony Chen, Lucia Dhanapal, Jay Tseu, Bing Pervaiz, Omer Peters, Louis Springett, Sally Danby, Robert Adele, Sandra Phillips, Eloise Malone, Tom Amini, Ali Stafford, Lizzie Deeks, Alexandra S. Dunachie, Susanna Klenerman, Paul Peniket, Andrew Barnes, Eleanor Kesavan, Murali |
author_facet | Murray, Sam M. Barbanti, Maria Campbell, Cori Brown, Anthony Chen, Lucia Dhanapal, Jay Tseu, Bing Pervaiz, Omer Peters, Louis Springett, Sally Danby, Robert Adele, Sandra Phillips, Eloise Malone, Tom Amini, Ali Stafford, Lizzie Deeks, Alexandra S. Dunachie, Susanna Klenerman, Paul Peniket, Andrew Barnes, Eleanor Kesavan, Murali |
author_sort | Murray, Sam M. |
collection | PubMed |
description | Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID‐19) and emerging variants. The optimal prophylactic vaccine strategy for this cohort is not defined. T cell‐mediated immunity is a critical component of graft‐versus‐tumour effect and in determining vaccine immunogenicity. Using validated anti‐spike (S) immunoglobulin G (IgG) and S‐specific interferon‐gamma enzyme‐linked immunospot (IFNγ‐ELIspot) assays we analysed response to a two‐dose vaccination schedule (either BNT162b2 or ChAdOx1) in 33 HSCT recipients at ≤2 years from transplant, alongside vaccine‐matched healthy controls (HCs). After two vaccines, infection‐naïve HSCT recipients had a significantly lower rate of seroconversion compared to infection‐naïve HCs (25/32 HSCT vs. 39/39 HCs no responders) and had lower S‐specific T‐cell responses. The HSCT recipients who received BNT162b2 had a higher rate of seroconversion compared to ChAdOx1 (89% vs. 74%) and significantly higher anti‐S IgG titres (p = 0.022). S‐specific T‐cell responses were seen after one vaccine in HCs and HSCT recipients. However, two vaccines enhanced S‐specific T‐cell responses in HCs but not in the majority of HSCT recipients. These data demonstrate limited immunogenicity of two‐dose vaccination strategies in HSCT recipients, bolstering evidence of the need for additional boosters and/or alternative prophylactic measures in this group. |
format | Online Article Text |
id | pubmed-9348196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93481962022-08-04 Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant Murray, Sam M. Barbanti, Maria Campbell, Cori Brown, Anthony Chen, Lucia Dhanapal, Jay Tseu, Bing Pervaiz, Omer Peters, Louis Springett, Sally Danby, Robert Adele, Sandra Phillips, Eloise Malone, Tom Amini, Ali Stafford, Lizzie Deeks, Alexandra S. Dunachie, Susanna Klenerman, Paul Peniket, Andrew Barnes, Eleanor Kesavan, Murali Br J Haematol Original Papers Allogeneic haematopoietic stem cell transplant (HSCT) recipients remain at high risk of adverse outcomes from coronavirus disease 2019 (COVID‐19) and emerging variants. The optimal prophylactic vaccine strategy for this cohort is not defined. T cell‐mediated immunity is a critical component of graft‐versus‐tumour effect and in determining vaccine immunogenicity. Using validated anti‐spike (S) immunoglobulin G (IgG) and S‐specific interferon‐gamma enzyme‐linked immunospot (IFNγ‐ELIspot) assays we analysed response to a two‐dose vaccination schedule (either BNT162b2 or ChAdOx1) in 33 HSCT recipients at ≤2 years from transplant, alongside vaccine‐matched healthy controls (HCs). After two vaccines, infection‐naïve HSCT recipients had a significantly lower rate of seroconversion compared to infection‐naïve HCs (25/32 HSCT vs. 39/39 HCs no responders) and had lower S‐specific T‐cell responses. The HSCT recipients who received BNT162b2 had a higher rate of seroconversion compared to ChAdOx1 (89% vs. 74%) and significantly higher anti‐S IgG titres (p = 0.022). S‐specific T‐cell responses were seen after one vaccine in HCs and HSCT recipients. However, two vaccines enhanced S‐specific T‐cell responses in HCs but not in the majority of HSCT recipients. These data demonstrate limited immunogenicity of two‐dose vaccination strategies in HSCT recipients, bolstering evidence of the need for additional boosters and/or alternative prophylactic measures in this group. John Wiley and Sons Inc. 2022-06-22 /pmc/articles/PMC9348196/ /pubmed/35655410 http://dx.doi.org/10.1111/bjh.18312 Text en © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Papers Murray, Sam M. Barbanti, Maria Campbell, Cori Brown, Anthony Chen, Lucia Dhanapal, Jay Tseu, Bing Pervaiz, Omer Peters, Louis Springett, Sally Danby, Robert Adele, Sandra Phillips, Eloise Malone, Tom Amini, Ali Stafford, Lizzie Deeks, Alexandra S. Dunachie, Susanna Klenerman, Paul Peniket, Andrew Barnes, Eleanor Kesavan, Murali Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant |
title | Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant |
title_full | Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant |
title_fullStr | Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant |
title_full_unstemmed | Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant |
title_short | Impaired humoral and cellular response to primary COVID‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant |
title_sort | impaired humoral and cellular response to primary covid‐19 vaccination in patients less than 2 years after allogeneic bone marrow transplant |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348196/ https://www.ncbi.nlm.nih.gov/pubmed/35655410 http://dx.doi.org/10.1111/bjh.18312 |
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