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Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts

OBJECTIVE: Targeting synovial fibroblasts (SF) using a cyclin-dependent kinase (CDK) 4/6 inhibitor (CDKI) could be a potent therapy for RA via inhibition of proliferation and MMP-3 production. This study was designed to elucidate the mechanism of chondroprotective effects on SFs by CDK 4/6 inhibitio...

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Detalles Bibliográficos
Autores principales:	Hosoya, Tadashi, Saito, Tetsuya, Baba, Hiroyuki, Tanaka, Nao, Noda, Seiji, Komiya, Youji, Tagawa, Yasuhiro, Yamamoto, Akio, Mizoguchi, Fumitaka, Kawahata, Kimito, Miyasaka, Nobuyuki, Kohsaka, Hitoshi, Yasuda, Shinsuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348617/ https://www.ncbi.nlm.nih.gov/pubmed/34849618 http://dx.doi.org/10.1093/rheumatology/keab874

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