ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

The coronavirus spike (S) glycoprotein attaches to host receptors and mediates viral fusion. Using a broad screening approach, we isolated from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune donors seven monoclonal antibodies (mAbs) that bind to all human-infecting coronavirus S...

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Detalles Bibliográficos
Autores principales: Low, Jun Siong, Jerak, Josipa, Tortorici, M. Alejandra, McCallum, Matthew, Pinto, Dora, Cassotta, Antonino, Foglierini, Mathilde, Mele, Federico, Abdelnabi, Rana, Weynand, Birgit, Noack, Julia, Montiel-Ruiz, Martin, Bianchi, Siro, Benigni, Fabio, Sprugasci, Nicole, Joshi, Anshu, Bowen, John E., Stewart, Cameron, Rexhepaj, Megi, Walls, Alexandra C., Jarrossay, David, Morone, Diego, Paparoditis, Philipp, Garzoni, Christian, Ferrari, Paolo, Ceschi, Alessandro, Neyts, Johan, Purcell, Lisa A., Snell, Gyorgy, Corti, Davide, Lanzavecchia, Antonio, Veesler, David, Sallusto, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348755/
https://www.ncbi.nlm.nih.gov/pubmed/35857703
http://dx.doi.org/10.1126/science.abq2679

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