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Assessment of disability in idiopathic inflammatory myopathy: a call for linearity

OBJECTIVES: To evaluate the clinimetric properties of the Academic Medical Centre Disability Score (ALDS) in patients with idiopathic inflammatory myopathy (IIM). METHODS: We used prospectively collected data of IIM patients who completed a phase-2 study with first-line IVIG monotherapy. The ALDS is...

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Autores principales: Min, Minoesch, Walter, Anne W, Lim, Johan, Eftimov, Filip, Verhamme, Camiel, de Visser, Marianne, van Schaik, Ivo N, Aggarwal, Rohit, de Haan, Rob J, van der Kooi, Anneke J, Raaphorst, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348770/
https://www.ncbi.nlm.nih.gov/pubmed/34875011
http://dx.doi.org/10.1093/rheumatology/keab906
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author Min, Minoesch
Walter, Anne W
Lim, Johan
Eftimov, Filip
Verhamme, Camiel
de Visser, Marianne
van Schaik, Ivo N
Aggarwal, Rohit
de Haan, Rob J
van der Kooi, Anneke J
Raaphorst, Joost
author_facet Min, Minoesch
Walter, Anne W
Lim, Johan
Eftimov, Filip
Verhamme, Camiel
de Visser, Marianne
van Schaik, Ivo N
Aggarwal, Rohit
de Haan, Rob J
van der Kooi, Anneke J
Raaphorst, Joost
author_sort Min, Minoesch
collection PubMed
description OBJECTIVES: To evaluate the clinimetric properties of the Academic Medical Centre Disability Score (ALDS) in patients with idiopathic inflammatory myopathy (IIM). METHODS: We used prospectively collected data of IIM patients who completed a phase-2 study with first-line IVIG monotherapy. The ALDS is a patient-reported questionnaire which contains 25 items relevant for disability in myositis. ALDS and all core set measures (CSMs) for myositis [including HAQ-Disability Index (HAQ-DI)] were evaluated at baseline and 9 weeks follow-up. In addition, the 2016 ACR/EULAR myositis response criteria outcome called Total Improvement Score (TIS) was evaluated at 9 weeks. We examined floor/ceiling effects, reliability and construct validity of the ALDS. To examine known-group validity, ALDS change scores over time were compared with TIS and physician impression of clinical response. RESULTS: Nineteen patients with IIM [median age 59 years, 12 (63%) female] were enrolled. At baseline, ALDS showed a median score of 65.4 (IQR 58.2–73.5), good Cronbach’s alpha (α = 0.84) and a small ceiling effect (11%). Construct validity was confirmed by moderate to strong correlations between ALDS and HAQ-DI [r(s) = −0.57 (baseline); −0.86 (follow-up)]. ALDS change score correlated with TIS (r(s) = 0.70), discriminated between responders and non-responders (TIS ≥ 40; P = 0.001), between groups based on physician impression of clinical response (P = 0.03), and detected deterioration. CONCLUSION: The ALDS showed promising clinimetric properties and detected relevant changes in disability in patients with myositis. These results warrant further investigations.
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spelling pubmed-93487702022-08-04 Assessment of disability in idiopathic inflammatory myopathy: a call for linearity Min, Minoesch Walter, Anne W Lim, Johan Eftimov, Filip Verhamme, Camiel de Visser, Marianne van Schaik, Ivo N Aggarwal, Rohit de Haan, Rob J van der Kooi, Anneke J Raaphorst, Joost Rheumatology (Oxford) Clinical Science OBJECTIVES: To evaluate the clinimetric properties of the Academic Medical Centre Disability Score (ALDS) in patients with idiopathic inflammatory myopathy (IIM). METHODS: We used prospectively collected data of IIM patients who completed a phase-2 study with first-line IVIG monotherapy. The ALDS is a patient-reported questionnaire which contains 25 items relevant for disability in myositis. ALDS and all core set measures (CSMs) for myositis [including HAQ-Disability Index (HAQ-DI)] were evaluated at baseline and 9 weeks follow-up. In addition, the 2016 ACR/EULAR myositis response criteria outcome called Total Improvement Score (TIS) was evaluated at 9 weeks. We examined floor/ceiling effects, reliability and construct validity of the ALDS. To examine known-group validity, ALDS change scores over time were compared with TIS and physician impression of clinical response. RESULTS: Nineteen patients with IIM [median age 59 years, 12 (63%) female] were enrolled. At baseline, ALDS showed a median score of 65.4 (IQR 58.2–73.5), good Cronbach’s alpha (α = 0.84) and a small ceiling effect (11%). Construct validity was confirmed by moderate to strong correlations between ALDS and HAQ-DI [r(s) = −0.57 (baseline); −0.86 (follow-up)]. ALDS change score correlated with TIS (r(s) = 0.70), discriminated between responders and non-responders (TIS ≥ 40; P = 0.001), between groups based on physician impression of clinical response (P = 0.03), and detected deterioration. CONCLUSION: The ALDS showed promising clinimetric properties and detected relevant changes in disability in patients with myositis. These results warrant further investigations. Oxford University Press 2021-12-07 /pmc/articles/PMC9348770/ /pubmed/34875011 http://dx.doi.org/10.1093/rheumatology/keab906 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Science
Min, Minoesch
Walter, Anne W
Lim, Johan
Eftimov, Filip
Verhamme, Camiel
de Visser, Marianne
van Schaik, Ivo N
Aggarwal, Rohit
de Haan, Rob J
van der Kooi, Anneke J
Raaphorst, Joost
Assessment of disability in idiopathic inflammatory myopathy: a call for linearity
title Assessment of disability in idiopathic inflammatory myopathy: a call for linearity
title_full Assessment of disability in idiopathic inflammatory myopathy: a call for linearity
title_fullStr Assessment of disability in idiopathic inflammatory myopathy: a call for linearity
title_full_unstemmed Assessment of disability in idiopathic inflammatory myopathy: a call for linearity
title_short Assessment of disability in idiopathic inflammatory myopathy: a call for linearity
title_sort assessment of disability in idiopathic inflammatory myopathy: a call for linearity
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348770/
https://www.ncbi.nlm.nih.gov/pubmed/34875011
http://dx.doi.org/10.1093/rheumatology/keab906
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