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Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility)
OBJECTIVES: Paternal preconception health is recognized as an important contributor to pregnancy outcomes. Nonetheless, pregnancy outcomes of partners of men with inflammatory arthritis (IA) have never been studied. Our objective was to describe the pregnancy outcomes of partners of men diagnosed wi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348772/ https://www.ncbi.nlm.nih.gov/pubmed/34875039 http://dx.doi.org/10.1093/rheumatology/keab910 |
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author | Perez-Garcia, Luis F Röder, Esther Smeele, Hieronymus T W Goekoop, Robbert Hazes, Johanna M W Kok, Marc R Tchetverikov, Ilja van der Helm-van Mil, Annette van der Kaap, Jos Kok, Petra Krijthe, Bouwe P Dolhain, Radboud J E M |
author_facet | Perez-Garcia, Luis F Röder, Esther Smeele, Hieronymus T W Goekoop, Robbert Hazes, Johanna M W Kok, Marc R Tchetverikov, Ilja van der Helm-van Mil, Annette van der Kaap, Jos Kok, Petra Krijthe, Bouwe P Dolhain, Radboud J E M |
author_sort | Perez-Garcia, Luis F |
collection | PubMed |
description | OBJECTIVES: Paternal preconception health is recognized as an important contributor to pregnancy outcomes. Nonetheless, pregnancy outcomes of partners of men with inflammatory arthritis (IA) have never been studied. Our objective was to describe the pregnancy outcomes of partners of men diagnosed with IA. METHODS: We performed a multicentre cross-sectional retrospective study conducted in the Netherlands. Men with IA who were over 40 years old that reported at least one positive pregnancy test were included. To analyse the impact of IA on pregnancy outcomes, pregnancies were classified into two groups: pregnancies conceived after the diagnosis of IA and before the diagnosis of IA. RESULTS: In total, 408 male participants diagnosed with IA reported 897 singleton pregnancies that resulted in 794 live births. Pregnancies conceived after the diagnosis of IA had higher rate of miscarriage (12.27 vs 7.53%, P = <0.05). This increased risk was still present after adjusting for confounders [OR 2.03 (95% CI 1.12, 3.69) P = 0.015]. CONCLUSIONS: This is the largest study to describe the pregnancy outcomes of partners of men diagnosed with IA and the first to demonstrate that paternal IA is associated with a higher risk of miscarriage. Notwithstanding, the overall rate of miscarriage reported in our study could be comparable to previously reported population estimates. |
format | Online Article Text |
id | pubmed-9348772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-93487722022-08-04 Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility) Perez-Garcia, Luis F Röder, Esther Smeele, Hieronymus T W Goekoop, Robbert Hazes, Johanna M W Kok, Marc R Tchetverikov, Ilja van der Helm-van Mil, Annette van der Kaap, Jos Kok, Petra Krijthe, Bouwe P Dolhain, Radboud J E M Rheumatology (Oxford) Clinical Science OBJECTIVES: Paternal preconception health is recognized as an important contributor to pregnancy outcomes. Nonetheless, pregnancy outcomes of partners of men with inflammatory arthritis (IA) have never been studied. Our objective was to describe the pregnancy outcomes of partners of men diagnosed with IA. METHODS: We performed a multicentre cross-sectional retrospective study conducted in the Netherlands. Men with IA who were over 40 years old that reported at least one positive pregnancy test were included. To analyse the impact of IA on pregnancy outcomes, pregnancies were classified into two groups: pregnancies conceived after the diagnosis of IA and before the diagnosis of IA. RESULTS: In total, 408 male participants diagnosed with IA reported 897 singleton pregnancies that resulted in 794 live births. Pregnancies conceived after the diagnosis of IA had higher rate of miscarriage (12.27 vs 7.53%, P = <0.05). This increased risk was still present after adjusting for confounders [OR 2.03 (95% CI 1.12, 3.69) P = 0.015]. CONCLUSIONS: This is the largest study to describe the pregnancy outcomes of partners of men diagnosed with IA and the first to demonstrate that paternal IA is associated with a higher risk of miscarriage. Notwithstanding, the overall rate of miscarriage reported in our study could be comparable to previously reported population estimates. Oxford University Press 2021-12-07 /pmc/articles/PMC9348772/ /pubmed/34875039 http://dx.doi.org/10.1093/rheumatology/keab910 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Science Perez-Garcia, Luis F Röder, Esther Smeele, Hieronymus T W Goekoop, Robbert Hazes, Johanna M W Kok, Marc R Tchetverikov, Ilja van der Helm-van Mil, Annette van der Kaap, Jos Kok, Petra Krijthe, Bouwe P Dolhain, Radboud J E M Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility) |
title | Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility) |
title_full | Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility) |
title_fullStr | Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility) |
title_full_unstemmed | Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility) |
title_short | Paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (iFAME-Fertility) |
title_sort | paternal inflammatory arthritis is associated with a higher risk of miscarriage: results of a large multicentre study (ifame-fertility) |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348772/ https://www.ncbi.nlm.nih.gov/pubmed/34875039 http://dx.doi.org/10.1093/rheumatology/keab910 |
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