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Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project

OBJECTIVES: It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association o...

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Autores principales: Estévez-López, Fernando, Guerrero-González, Juan M, Salazar-Tortosa, Diego, Camiletti-Moirón, Daniel, Gavilán-Carrera, Blanca, Aparicio, Virginia A, Acosta-Manzano, Pedro, Álvarez-Gallardo, Inmaculada C, Segura-Jiménez, Víctor, Soriano-Maldonado, Alberto, Geenen, Rinie, Delgado-Fernández, Manuel, Martínez-González, Luis J, Ruiz, Jonatan R, Álvarez-Cubero, María J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348776/
https://www.ncbi.nlm.nih.gov/pubmed/34875034
http://dx.doi.org/10.1093/rheumatology/keab911
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author Estévez-López, Fernando
Guerrero-González, Juan M
Salazar-Tortosa, Diego
Camiletti-Moirón, Daniel
Gavilán-Carrera, Blanca
Aparicio, Virginia A
Acosta-Manzano, Pedro
Álvarez-Gallardo, Inmaculada C
Segura-Jiménez, Víctor
Soriano-Maldonado, Alberto
Geenen, Rinie
Delgado-Fernández, Manuel
Martínez-González, Luis J
Ruiz, Jonatan R
Álvarez-Cubero, María J
author_facet Estévez-López, Fernando
Guerrero-González, Juan M
Salazar-Tortosa, Diego
Camiletti-Moirón, Daniel
Gavilán-Carrera, Blanca
Aparicio, Virginia A
Acosta-Manzano, Pedro
Álvarez-Gallardo, Inmaculada C
Segura-Jiménez, Víctor
Soriano-Maldonado, Alberto
Geenen, Rinie
Delgado-Fernández, Manuel
Martínez-González, Luis J
Ruiz, Jonatan R
Álvarez-Cubero, María J
author_sort Estévez-López, Fernando
collection PubMed
description OBJECTIVES: It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate genes) and the gene–gene, gene–PA and gene–sedentary behaviour interactions with pain and pain-related cognitions in women with FM. METHODS: Saliva samples from 274 women with FM [mean (s.d.) age 51.7 (7.7) years] were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed. RESULTS: The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid receptor μ gene, OPRM1) was related to pain catastrophizing. Five gene–behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of FM symptoms (codominant model, P-value 0.032). CONCLUSION: The HTR2A gene (individually), COMT and OPRM1 gene–gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene–sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain.
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spelling pubmed-93487762022-08-04 Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project Estévez-López, Fernando Guerrero-González, Juan M Salazar-Tortosa, Diego Camiletti-Moirón, Daniel Gavilán-Carrera, Blanca Aparicio, Virginia A Acosta-Manzano, Pedro Álvarez-Gallardo, Inmaculada C Segura-Jiménez, Víctor Soriano-Maldonado, Alberto Geenen, Rinie Delgado-Fernández, Manuel Martínez-González, Luis J Ruiz, Jonatan R Álvarez-Cubero, María J Rheumatology (Oxford) Clinical Science OBJECTIVES: It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate genes) and the gene–gene, gene–PA and gene–sedentary behaviour interactions with pain and pain-related cognitions in women with FM. METHODS: Saliva samples from 274 women with FM [mean (s.d.) age 51.7 (7.7) years] were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed. RESULTS: The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid receptor μ gene, OPRM1) was related to pain catastrophizing. Five gene–behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of FM symptoms (codominant model, P-value 0.032). CONCLUSION: The HTR2A gene (individually), COMT and OPRM1 gene–gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene–sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain. Oxford University Press 2021-12-07 /pmc/articles/PMC9348776/ /pubmed/34875034 http://dx.doi.org/10.1093/rheumatology/keab911 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Science
Estévez-López, Fernando
Guerrero-González, Juan M
Salazar-Tortosa, Diego
Camiletti-Moirón, Daniel
Gavilán-Carrera, Blanca
Aparicio, Virginia A
Acosta-Manzano, Pedro
Álvarez-Gallardo, Inmaculada C
Segura-Jiménez, Víctor
Soriano-Maldonado, Alberto
Geenen, Rinie
Delgado-Fernández, Manuel
Martínez-González, Luis J
Ruiz, Jonatan R
Álvarez-Cubero, María J
Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project
title Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project
title_full Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project
title_fullStr Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project
title_full_unstemmed Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project
title_short Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project
title_sort interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-ándalus project
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348776/
https://www.ncbi.nlm.nih.gov/pubmed/34875034
http://dx.doi.org/10.1093/rheumatology/keab911
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