Cargando…
Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing
The mechanoelectrical transduction (MET) channel in auditory hair cells converts sound into electrical signals, enabling hearing. Transmembrane-like channel 1 and 2 (TMC1 and TMC2) are implicated in forming the pore of the MET channel. Here, we demonstrate that inhibition of MET channels, breakage o...
Autores principales: | Ballesteros, Angela, Swartz, Kenton J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348795/ https://www.ncbi.nlm.nih.gov/pubmed/35921424 http://dx.doi.org/10.1126/sciadv.abm5550 |
Ejemplares similares
-
The contribution of TMC1 to adaptation of mechanoelectrical transduction channels in cochlear outer hair cells
por: Goldring, Adam C., et al.
Publicado: (2019) -
A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells
por: Beurg, Maryline, et al.
Publicado: (2019) -
Ultrastructural localization of the likely mechanoelectrical transduction channel protein, transmembrane-like channel 1 (TMC1) during development of cochlear hair cells
por: Mahendrasingam, Shanthini, et al.
Publicado: (2019) -
TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells
por: Corns, Laura F., et al.
Publicado: (2017) -
Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice
por: Wang, Yanfei, et al.
Publicado: (2017)