A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development

Current therapies remain unsatisfactory in preventing the recurrence of glioblastoma multiforme (GBM), which leads to poor patient survival. By rational engineering of the transcription factor SOX2, a key promoter of GBM malignancy, together with the Kruppel-associated box and DNA methyltransferase3...

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Detalles Bibliográficos
Autores principales: Benedetti, Valerio, Banfi, Federica, Zaghi, Mattia, Moll-Diaz, Raquel, Massimino, Luca, Argelich, Laura, Bellini, Edoardo, Bido, Simone, Muggeo, Sharon, Ordazzo, Gabriele, Mastrototaro, Giuseppina, Moneta, Matteo, Sessa, Alessandro, Broccoli, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348799/
https://www.ncbi.nlm.nih.gov/pubmed/35921410
http://dx.doi.org/10.1126/sciadv.abn3986

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