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Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells

Type 1 regulatory T (Tr1) cells represent a subset of IL-10–producing CD4(+)Foxp3(−) T cells and play key roles in promoting transplant tolerance. However, no effective pharmacological approaches have been able to induce Tr1 cells in vivo. We herein report the combined use of a CD28 superagonist (D6...

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Detalles Bibliográficos
Autores principales:	Que, Weitao, Ma, Kuai, Hu, Xin, Guo, Wen-Zhi, Li, Xiao-Kang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348800/ https://www.ncbi.nlm.nih.gov/pubmed/35921418 http://dx.doi.org/10.1126/sciadv.abo4413

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