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Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

Transcriptional variability facilitates stochastic cell diversification and can in turn underpin adaptation to stress or injury. We hypothesize that it may analogously facilitate progression of premalignancy to cancer. To investigate this, we initiated preleukemia in mouse cells with enhanced transc...

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Detalles Bibliográficos
Autores principales:	Gupta, Shikha, Dovey, Oliver M., Domingues, Ana Filipa, Cyran, Oliwia W., Cash, Caitlin M., Giotopoulos, George, Rak, Justyna, Cooper, Jonathan, Gozdecka, Malgorzata, Dijkhuis, Liza, Asby, Ryan J., Al-Jabery, Noor, Hernandez-Hernandez, Victor, Prabakaran, Sudhakaran, Huntly, Brian J., Vassiliou, George S., Pina, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348803/ https://www.ncbi.nlm.nih.gov/pubmed/35921412 http://dx.doi.org/10.1126/sciadv.abn4886

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