A Co-conformationally “Topologically” Chiral Catenane

[Image: see text] Catenanes composed of two achiral rings that are oriented (C(nh) symmetry) because of the sequence of atoms they contain are referred to as topologically chiral. Here, we present the synthesis of a highly enantioenriched catenane containing a related but overlooked “co-conformation...

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Detalles Bibliográficos
Autores principales: Rodríguez-Rubio, Arnau, Savoini, Andrea, Modicom, Florian, Butler, Patrick, Goldup, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348828/
https://www.ncbi.nlm.nih.gov/pubmed/35763555
http://dx.doi.org/10.1021/jacs.2c02029
Descripción
Sumario:[Image: see text] Catenanes composed of two achiral rings that are oriented (C(nh) symmetry) because of the sequence of atoms they contain are referred to as topologically chiral. Here, we present the synthesis of a highly enantioenriched catenane containing a related but overlooked “co-conformationally ‘topologically’ chiral” stereogenic unit, which arises when a bilaterally symmetric C(nv) ring is desymmetrized by the position of an oriented macrocycle.

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