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Five Percent Variant Allele Frequency Is a Reliable Reporting Threshold for TP53 Variants Detected by Next Generation Sequencing in Chronic Lymphocytic Leukemia in the Clinical Setting

The clinical significance of small TP53 clones detected with next generation sequencing (NGS) in chronic lymphocytic leukemia is an issue of active debate. According to the official guidelines, treatment decisions should be guided only by variants with variant allele frequency (VAF) ≥10%. We present...

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Detalles Bibliográficos
Autores principales:	Pandzic, Tatjana, Ladenvall, Claes, Engvall, Marie, Mattsson, Mattias, Hermanson, Monica, Cavelier, Lucia, Ljungström, Viktor, Baliakas, Panagiotis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348859/ https://www.ncbi.nlm.nih.gov/pubmed/35935605 http://dx.doi.org/10.1097/HS9.0000000000000761

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